Histological confirmation of endometriosis in a 9-year-old girl suffering from unexplained cyclic pelvic pain

This case report describes a nine-year-old girl presenting with unexplained cyclic pelvic pain who was evaluated at the Endometriosis Research Center Berlin-Brandenburg. The clinical workup included medical history, physical examination, ultrasound, and laboratory tests, culminating in a laparoscopic resection of visible lesions for histological analysis. Pathological confirmation revealed endometrial-like glands and stromal tissue expressing CD10, definitively diagnosing endometriosis in this premenarcheal patient. The authors conclude that endometriosis should be considered in the differential diagnosis of cyclic pelvic pain in young girls, challenging the view that it is exclusively a disease of reproductive-age women. This paper is centrally about endometriosis — specifically its occurrence and histological confirmation in a pediatric patient.

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