COFFEE CONSUMPTION AND PREVALENCE OF INSOMNIA DISORDER IN MEDICAL INTERNS AT THE AUTONOMOUS UNIVERSITY OF SANTO DOMINGO, DOMINICAN REPUBLIC, SEPTEMBER 2022-MARCH 2023

preprint OA: closed
📄 Open PDF Full text JSON View at publisher
AI-generated summary by claude@2026-07, 2026-07-05

This study investigated the relationship between coffee consumption and insomnia disorder prevalence among medical interns at UASD from September 2022 to March 2023.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-07, 2026-07-05 · read from full text

This cross-sectional, descriptive quantitative study examined the relationship between coffee consumption and insomnia in 299 medical interns at the Autonomous University of Santo Domingo (September 2022–March 2023), using a 15-question online survey that classified participants based on DSM-5 diagnostic criteria into groups with insomnia, with insomnia criteria, or without insomnia. The authors reported that higher daily coffee consumption was associated with a higher prevalence of insomnia and insomnia symptoms, with interns who consumed coffee daily showing greater insomnia incidence; prevalence was also presented separately by gender. A major limitation is that the study used self-reported survey data and a cross-sectional design, which does not establish causality. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 23,232 characters · extracted from preprint-html · click to expand
COFFEE CONSUMPTION AND PREVALENCE OF INSOMNIA DISORDER IN MEDICAL INTERNS AT THE AUTONOMOUS UNIVERSITY OF SANTO DOMINGO, DOMINICAN REPUBLIC, SEPTEMBER 2022-MARCH 2023 | medRxiv /* */ /* */ <!-- <!-- /*! * yepnope1.5.4 * (c) WTFPL, GPLv2 */ (function(a,b,c){function d(a){return"[object Function]"==o.call(a)}function e(a){return"string"==typeof a}function f(){}function g(a){return!a||"loaded"==a||"complete"==a||"uninitialized"==a}function h(){var a=p.shift();q=1,a?a.t?m(function(){("c"==a.t?B.injectCss:B.injectJs)(a.s,0,a.a,a.x,a.e,1)},0):(a(),h()):q=0}function i(a,c,d,e,f,i,j){function k(b){if(!o&&g(l.readyState)&&(u.r=o=1,!q&&h(),l.onload=l.onreadystatechange=null,b)){"img"!=a&&m(function(){t.removeChild(l)},50);for(var d in y[c])y[c].hasOwnProperty(d)&&y[c][d].onload()}}var j=j||B.errorTimeout,l=b.createElement(a),o=0,r=0,u={t:d,s:c,e:f,a:i,x:j};1===y[c]&&(r=1,y[c]=[]),"object"==a?l.data=c:(l.src=c,l.type=a),l.width=l.height="0",l.onerror=l.onload=l.onreadystatechange=function(){k.call(this,r)},p.splice(e,0,u),"img"!=a&&(r||2===y[c]?(t.insertBefore(l,s?null:n),m(k,j)):y[c].push(l))}function j(a,b,c,d,f){return q=0,b=b||"j",e(a)?i("c"==b?v:u,a,b,this.i++,c,d,f):(p.splice(this.i++,0,a),1==p.length&&h()),this}function k(){var a=B;return a.loader={load:j,i:0},a}var l=b.documentElement,m=a.setTimeout,n=b.getElementsByTagName("script")[0],o={}.toString,p=[],q=0,r="MozAppearance"in l.style,s=r&&!!b.createRange().compareNode,t=s?l:n.parentNode,l=a.opera&&"[object Opera]"==o.call(a.opera),l=!!b.attachEvent&&!l,u=r?"object":l?"script":"img",v=l?"script":u,w=Array.isArray||function(a){return"[object Array]"==o.call(a)},x=[],y={},z={timeout:function(a,b){return b.length&&(a.timeout=b[0]),a}},A,B;B=function(a){function b(a){var a=a.split("!"),b=x.length,c=a.pop(),d=a.length,c={url:c,origUrl:c,prefixes:a},e,f,g;for(f=0;f<d;f++)g=a[f].split("="),(e=z[g.shift()])&&(c=e(c,g));for(f=0;f<b;f++)c=x[f](c);return c}function g(a,e,f,g,h){var i=b(a),j=i.autoCallback;i.url.split(".").pop().split("?").shift(),i.bypass||(e&&(e=d(e)?e:e[a]||e[g]||e[a.split("/").pop().split("?")[0]]),i.instead?i.instead(a,e,f,g,h):(y[i.url]?i.noexec=!0:y[i.url]=1,f.load(i.url,i.forceCSS||!i.forceJS&&"css"==i.url.split(".").pop().split("?").shift()?"c":c,i.noexec,i.attrs,i.timeout),(d(e)||d(j))&&f.load(function(){k(),e&&e(i.origUrl,h,g),j&&j(i.origUrl,h,g),y[i.url]=2})))}function h(a,b){function c(a,c){if(a){if(e(a))c||(j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}),g(a,j,b,0,h);else if(Object(a)===a)for(n in m=function(){var b=0,c;for(c in a)a.hasOwnProperty(c)&&b++;return b}(),a)a.hasOwnProperty(n)&&(!c&&!--m&&(d(j)?j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}:j[n]=function(a){return function(){var b=[].slice.call(arguments);a&&a.apply(this,b),l()}}(k[n])),g(a[n],j,b,n,h))}else!c&&l()}var h=!!a.test,i=a.load||a.both,j=a.callback||f,k=j,l=a.complete||f,m,n;c(h?a.yep:a.nope,!!i),i&&c(i)}var i,j,l=this.yepnope.loader;if(e(a))g(a,0,l,0);else if(w(a))for(i=0;i (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0];var j=d.createElement(s);var dl=l!='dataLayer'?'&l='+l:'';j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;j.type='text/javascript';j.async=true;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-P4HH5NV'); Skip to main content Home About Submit ALERTS / RSS Search for this keyword Advanced Search COFFEE CONSUMPTION AND PREVALENCE OF INSOMNIA DISORDER IN MEDICAL INTERNS AT THE AUTONOMOUS UNIVERSITY OF SANTO DOMINGO, DOMINICAN REPUBLIC, SEPTEMBER 2022-MARCH 2023 View ORCID Profile Andy Bienvenido Ogando Montero , View ORCID Profile Inomar Nuñez Figuereo doi: https://doi.org/10.1101/2024.11.18.24317358 Andy Bienvenido Ogando Montero 1 Autonomous University of Santo Domingo INSIS-UASD, National District , Dominican Republic Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Andy Bienvenido Ogando Montero Inomar Nuñez Figuereo 1 Autonomous University of Santo Domingo INSIS-UASD, National District , Dominican Republic Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Inomar Nuñez Figuereo For correspondence: inomarnf{at}gmail.com Abstract Full Text Info/History Metrics Data/Code Preview PDF Abstract This study aims to investigate the relationship between insomnia and coffee consumption among medical interns at the Autonomous University of Santo Domingo, Dominican Republic. The research stems from the observation of high coffee consumption among healthcare personnel, particularly those exposed to night shifts and conditions that impact sleep quality. A cross-sectional, descriptive, and quantitative study was conducted with a sample of 299 interns, divided into groups based on the presence or absence of insomnia symptoms according to DSM-V criteria. The results indicate a significant relationship between coffee consumption and the prevalence of insomnia, with higher incidence among interns who consume coffee daily. This study provides evidence on how coffee consumption, within the Dominican cultural context and the demands of the medical environment, can affect sleep quality among medical interns. These findings highlight the need to consider caffeine consumption as a potential factor in the assessment and management of sleep disorders within this group of healthcare professionals. Introduction This study aims to shed scientific light on observable behaviors among our colleagues in the Faculty of Health Sciences. Here, we intend to determine the relationship between insomnia and coffee consumption. In the Dominican Republic, drinking coffee is a deeply rooted tradition. Unlike other coffee-producing countries, domestic coffee consumption in this country is significant. National coffee demand was estimated at 2.81 kg of ground coffee per person in 2021 (Jiménez et al., 2007). Healthcare personnel are also part of the general population and, therefore, are coffee consumers. Moreover, this group is often exposed to additional factors, such as night shifts, which cause not only tiredness but exhaustion, as short sleep periods are impossible, and the fatigue generated by staying awake for long hours at night is hard to compensate. In this study, however, we will focus exclusively on coffee consumption as a variable to assess its relationship with the prevalence of insomnia. Methods This is a cross-sectional, descriptive, quantitative study. The study population consisted of medical interns at the UASD (Universidad Autónoma de Santo Domingo) completing their rotational internship during the periods of September 2022 and March 2023. We used simple random sampling to select the participants, dividing them into three groups: Interns with insomnia. Interns meeting diagnostic criteria for insomnia according to the DSM-5 (The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition). Interns without insomnia. Survey Instrument Data were collected using a 15-question structured survey, which was designed to classify participants into the three aforementioned categories and further separate them by gender. The survey included the following topics: Topic 1: age, gender. Topic 2: Sleep habits and symptoms, incorporating validated criteria from the DSM-5 to identify insomnia symptoms and diagnose insomnia. Topic 3: Coffee consumption habits, including: Frequency of coffee intake. Number of cups consumed per day. Time of day when coffee is consumed. Study Population and Sampling The target population consisted of 1,356 medical interns in the September 2022/2023 and March 2023/2024 rotations in hospitals affiliated with the UASD School of Medicine. Using Epi Info 7.2, we calculated a required sample size of 299 participants to achieve a 95% confidence interval and a margin of error of 5%. Participants were selected randomly from the complete list of interns provided by the university administration. Data Collection Process Participants were invited to complete the survey via an online platform, ensuring anonymity and confidentiality. The survey system was programmed to classify participants automatically into one of the three groups based on their responses: Interns with insomnia: Those meeting the DSM-5 diagnostic criteria. Interns meeting partial criteria: Those with symptoms consistent with insomnia but insufficient to meet the full diagnostic criteria. Interns without insomnia: Those reporting no symptoms of insomnia. Ethical Considerations The study protocol was approved by the Ethics Committee of the UASD School of Medicine. Informed consent was obtained from all participants before administering the survey. Data Analysis Data were analyzed using descriptive, inferential, and correlational statistics. Descriptive statistics summarized the prevalence of insomnia and coffee consumption by gender and category (Insomnia, With Criteria, Without Insomnia). Inferential statistics were used to evaluate differences between groups, assessing statistical significance at a 95% confidence level. A correlation analysis was performed to explore the relationship between daily coffee consumption and the prevalence of insomnia across the three categories (Insomnia, With Criteria, Without Insomnia). Pearson’s correlation coefficient was calculated to measure the strength and direction of the association, and significance was determined at the p < 0.05 level. The results were visualized to illustrate patterns by gender and category, highlighting differences in coffee consumption and insomnia prevalence. This comprehensive approach allowed for a deeper understanding of the factors contributing to insomnia and their association with coffee consumption, providing insights into gender-specific patterns and their implications. Supplementary Materials The complete survey instrument, including all sections and questions, has been provided as a supplemental file to allow qualified readers to follow and replicate. Questionary Are you diagnosed with an insomnia disorder? Responses: Yes / No. Gender: Responses: Male / Female. Do you consume coffee? Responses: Yes / No. Do you drink coffee? Responses: Yes / No. How many cups of coffee do you drink daily? Responses: I don’t drink coffee / 1 / 2 / 3 / 4 or more. How many cups of coffee do you consume per day? Responses: I don’t drink coffee / 1 / 2 / 3 / 4 or more. How many cups do you drink per day? Responses: I don’t drink coffee / 1 / 2 / 3 / 4 or more. How many cups of coffee do you drink in a day? Responses: I don’t drink coffee / 1 / 2 / 3 / 4 or more. Gender: Responses: Male / Female. Do you drink coffee? Responses: Yes / No. Do you drink coffee? Responses: Yes / No. How many cups of coffee do you consume daily? Responses: I don’t drink coffee / 1 / 2 / 3 / 4 or more. How many cups of coffee do you drink per day? Responses: I don’t drink coffee / 1 / 2 / 3 / 4 or more. Have you experienced any of the following events? Responses: Difficulty initiating sleep. Difficulty maintaining sleep. Poor sleep quality. None. How many cups of coffee do you drink per day? Responses: I don’t drink coffee / 1 / 2 / 3 / 4 or more. View this table: View inline View popup Download powerpoint Results The findings of this research indicate a relationship between coffee consumption and the prevalence of insomnia and/or symptoms thereof (criteria). A total of 299 interns were surveyed, consisting of 61 men and 238 women ( Table #1 ). View this table: View inline View popup Download powerpoint Table 1. For the 61 men, the following data were obtained: 17 (28%) without insomnia, 35 (57%) with criteria, and 9 (15%) with insomnia ( Table #2 ). For the 238 women, the following data were obtained: 58 (24%) without insomnia, 166 (70%) with criteria, and 14 (6%) with insomnia ( Table #3 ). The number of interns who reported coffee consumption was higher in both sexes and across all categories than those who did not consume coffee. Among the population presenting criteria and/or insomnia, totaling 226 individuals, 144 (63%) consumed coffee, while 82 (36%) did not. This indicates a higher prevalence of insomnia among coffee consumers ( Table #4 ). There is a trend toward higher daily coffee intake among those with insomnia (1.8 cups for men; 2.1 cups for women) and those with diagnostic criteria (1.9 cups for men; 1.7 cups for women) than among those without insomnia (1.4 cups for men; 1.2 cups for women) ( Table #5 ). Among women, there is a directly proportional relationship between coffee consumption and insomnia prevalence, with a higher number of cups corresponding to a higher prevalence of criteria and/or insomnia (1.7 cups; 2.1 cups, respectively) ( Table #5 ). An atypical relationship was observed in men, where those meeting criteria consumed an average of 1.9 cups per day, higher than those with insomnia (1.8 cups). This may be due to other factors, including diet-hygienic or diet-therapeutic measures that might require lower coffee consumption among those diagnosed. While we cannot confirm this, future studies could explore this hypothesis. Nonetheless, the mean coffee consumption across all categories and in both sexes was lower for those without insomnia. We determined that there is no significant relationship between coffee consumption and gender, as percentages were very similar in both groups ( Table #5 ). View this table: View inline View popup Download powerpoint Table 2. View this table: View inline View popup Download powerpoint Table 3. View this table: View inline View popup Download powerpoint Table 4. View this table: View inline View popup Download powerpoint Table 5. Discussion The consumption of coffee among medical interns was higher than described in other studies, although the relationship between insomnia and clinical symptoms of insomnia is similar, as shown in the study by Abdelmoaty Goweda R, Hassan-Hussein A. in 2020, in their article “Prevalence of sleep disorders among medical students of Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia . ” In this study, 73.8% of participants had sleep disorders, a percentage very similar to our study, which reported 74% on average for both sexes. Similarly, the results of the study “Use of energy drinks and symptoms of insomnia in medical students of a Peruvian university” by Mendoza L. Marco G, demonstrate the prevalence of insomnia symptoms in the studied sample, which consumed energy drinks (high levels of caffeine). These findings align with the data shown in this study. Based on the presented results, we define the relationship between coffee consumption and the prevalence of insomnia, which should be considered as an associated factor. Data Availability All data produced in the present work are contained in the manuscript Declaration of Conflicts of Interest There are no conflicts of interest in this study. References 1. Marco G. Mendoza L. , Gonzalo Cornejo V. , Ali Al-kassab C. , Álvaro A. Rosales K. , Bruno S . Chávez R. , Germán F. Alvarado . Use of energy drinks and insomnia symptoms in medical students at a Peruvian university . Rev. chil. neuro-psiquiatr. [Internet] . 2021 Dec [cited 2023 Jul 10 ]; 59 ( 4 ): 289 – 301 . Available from: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-92272021000400289&lng=es . OpenUrl 2. Osada Liy Jorge Enrique , Rojas Villegas Miguel Oswaldo , Rosales Vásquez César Eduardo , Vega Dienstmaier Johann . Caffeine consumption in medical students and its coexistence with anxiety and depressive symptoms . Rev Med Hered [Internet] . 2008 Jul [cited 2023 Jul 10 ]; 19 ( 3 ): 102 – 107 . Available from: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1018-130X2008000300004&lng=es . OpenUrl 3. Carnevali de Falke Susana , Degrossi María Claudia . Excessive caffeine consumption and potential at-risk populations . Acta toxicol. argent. [Internet] . 2017 Dec [cited 2023 Jul 10 ]; 25 ( 3 ): 67 – 79 . Available from: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432017000300001&lng=es . OpenUrl 4. Durán Agüero Samuel , Cediel Giraldo Gustavo , Brignardello Guerra Jerusa . Relationship between nutritional status and sleep duration in Chilean school-age children . ALAN [Internet] . 2017 Mar [cited 2023 Jul 10 ]; 67 ( 1 ): 01 – 05 . Available from: http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0004-06222017000100001&lng=es . OpenUrl 5. Martínez Hernández Olivia , Montalván Martínez Olivia , Betancourt Izquierdo Yandy . Insomnia disorder. Current considerations . Rev.Med.Electrón. [Internet] . 2019 Apr [cited 2023 Jul 10 ]; 41 ( 2 ): 483 – 495 . Available from: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1684-18242019000200483&lng=es . OpenUrl 6. Torres-Ugalde Yeyetzi Citlali , Romero-Palencia Angélica , Román-Gutiérrez Alma Delia . Physiological and cognitive effects of caffeine in childhood: systematic review of the literature . Rev Esp Nutr Hum Diet [Internet] . 2020 Dec [cited 2023 Jul 11 ]; 24 ( 4 ): 345 – 356 . Available from: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2174-51452020000400006&lng=es . Epub 25-Oct-2021. doi: 10.14306/renhyd.24.4.1041 . OpenUrl CrossRef 7. Hernando-Requejo Ovidio , Hernando-Requejo Virgilio , Requejo Marcos Ana María . The impact of nutrition in fighting insomnia . Nutr. Hosp. [Internet] . 2020 [cited 2023 Jul 11 ]; 37 ( pe2 ): 57 – 62 . Available from: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112020000600013&lng=es . Epub 28-Dec-2020. doi: 10.20960/nh.03359 . OpenUrl CrossRef 8. Ramírez Prada Dianna Mayrene . Coffee, caffeine vs. health: A review of the effects of coffee consumption on health . Univ. Salud [Internet] . 2010 [cited 2023 Jul 10 ]; 12 ( 1 ): 156 – 167 . Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0124-71072010000100017&lng=en . OpenUrl 9. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders (DSM-5) . 5th ed. Arlington, VA : American Psychiatric Association ; 2014 . 10. Abdelmoaty Goweda R , Hassan-Hussein A , Ali Alqahtani M , Janaini MM , Alzahrani AH , Sindy BM , et al. Prevalence of sleep disorders among medical students of Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia . J Public Health Res [Internet] . 2020 [cited 2023 Jul 11 ]; 9 ( Suppl 1 ): 2020 . Available from: 10.4081/jphr.2020.1921 OpenUrl 11. García Gascón Ángel , Querts Méndez Odalis , Hernández González Raúl César , Agüero Martén Raiza , Cascaret Soto Xiomara . Biological variables related to sleep disorders in first-year medical students . MEDISAN [Internet] . 2015 Aug [cited 2023 Jul 11 ]; 19 ( 8 ): 978 – 983 . Available from: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192015000800007&lng=es OpenUrl 12. Kim SY , Sim S , Choi HG . High stress, lack of sleep, low school performance, and suicide attempts are associated with high energy drink intake in adolescents . PLoS One [Internet] . 2017 [cited 2023 Jul 11 ]; 12 ( 11 ): e0187759 . Available from : doi: 10.1371/journal.pone.0187759 OpenUrl CrossRef View the discussion thread. Back to top Previous Next Posted November 19, 2024. Download PDF Data/Code Email Thank you for your interest in spreading the word about medRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following COFFEE CONSUMPTION AND PREVALENCE OF INSOMNIA DISORDER IN MEDICAL INTERNS AT THE AUTONOMOUS UNIVERSITY OF SANTO DOMINGO, DOMINICAN REPUBLIC, SEPTEMBER 2022-MARCH 2023 Message Subject (Your Name) has forwarded a page to you from medRxiv Message Body (Your Name) thought you would like to see this page from the medRxiv website. Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Share COFFEE CONSUMPTION AND PREVALENCE OF INSOMNIA DISORDER IN MEDICAL INTERNS AT THE AUTONOMOUS UNIVERSITY OF SANTO DOMINGO, DOMINICAN REPUBLIC, SEPTEMBER 2022-MARCH 2023 Andy Bienvenido Ogando Montero , Inomar Nuñez Figuereo medRxiv 2024.11.18.24317358; doi: https://doi.org/10.1101/2024.11.18.24317358 Share This Article: Copy Citation Tools COFFEE CONSUMPTION AND PREVALENCE OF INSOMNIA DISORDER IN MEDICAL INTERNS AT THE AUTONOMOUS UNIVERSITY OF SANTO DOMINGO, DOMINICAN REPUBLIC, SEPTEMBER 2022-MARCH 2023 Andy Bienvenido Ogando Montero , Inomar Nuñez Figuereo medRxiv 2024.11.18.24317358; doi: https://doi.org/10.1101/2024.11.18.24317358 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Area Addiction Medicine Subject Areas All Articles Addiction Medicine (573) Allergy and Immunology (865) Anesthesia (304) Cardiovascular Medicine (4457) Dentistry and Oral Medicine (445) Dermatology (383) Emergency Medicine (610) Endocrinology (including Diabetes Mellitus and Metabolic Disease) (1517) Epidemiology (15244) Forensic Medicine (30) Gastroenterology (1132) Genetic and Genomic Medicine (6620) Geriatric Medicine (669) Health Economics (1002) Health Informatics (4557) Health Policy (1372) Health Systems and Quality Improvement (1615) Hematology (543) HIV/AIDS (1272) Infectious Diseases (except HIV/AIDS) (15936) Intensive Care and Critical Care Medicine (1106) Medical Education (624) Medical Ethics (147) Nephrology (670) Neurology (6635) Nursing (346) Nutrition (999) Obstetrics and Gynecology (1148) Occupational and Environmental Health (957) Oncology (3348) Ophthalmology (980) Orthopedics (369) Otolaryngology (421) Pain Medicine (436) Palliative Medicine (130) Pathology (665) Pediatrics (1696) Pharmacology and Therapeutics (693) Primary Care Research (714) Psychiatry and Clinical Psychology (5463) Public and Global Health (9257) Radiology and Imaging (2210) Rehabilitation Medicine and Physical Therapy (1371) Respiratory Medicine (1198) Rheumatology (598) Sexual and Reproductive Health (716) Sports Medicine (532) Surgery (714) Toxicology (99) Transplantation (289) Urology (265) (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'a034d63a5f88ecda',t:'MTc4MDA1MDc2Mw=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: preprint-html

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2024) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

europepmc
last seen: 2026-05-19T01:45:01.086888+00:00