Study on Effectiveness of Danazol-loaded Intrauterine Device in Treating Experimentally Induced Uterine Adenomyosis in the Mice

Objective To explore the effectiveness of danazol-loaded intrauterine device in treating experimentally induced uterine adenomyosis in the ICR mice.Methods ICR mice model of uterine adenomyosis was induced by pituitary grafting to investigate the effectiveness of danazol-loaded intrauterine device.Results After utilization of danazol-loaded intrauterine device for 2 months,the results of different groups were compared and analyzed.Uterine wet weight/body weight ratio and the number of extrauterine nodules and the grading score of HE staining of treated group were less than that of untreated group.The results of danazol-loaded intrauterine device group were the same as that of danazol orally-taking group.Conclusions The danazol-loaded intrauterine device can treat experimentally induced uterine adenomyosis in the ICR mice effectively.Further clinical trial can be performed.