Observation on clinical efficacy of alareilin in preventing recurrence of ovarian endometriosis cyst after operation

Objective To investigate the clinical efficacy of alareilin in preventing the recurrence of ovarian endometriosis cyst(OEC) after the operation. Methods Retrospectively collected 54 patients with OEC in Tianjin Meizhong Yihe Women and Children's Hospital from March 2008 to December 2010 as the research object. The patients were accepted the operation of laparoscopic cyst removed,and they were im administered with alareilin 150 μg/d on day 1 of the first menstruation after the operation,and lasted for 5 d. Every 4 week was as one cycle,and they were continuously treated for six cycles. Fifty patients with OEC,who were accepted pure operation of laparoscopic cyst removed in the same period,were as control. Clinical efficacy,recurrence time,accumulated recurrence rate,and cumulative survival rate were compared by referring to the history. Results The total effective rates of the patients in the treatment and control groups were 92.59% and 78.00%,respectively,with the significant difference between the two groups(P 0.05). The average recurrence time of the patients in the treatment group was(24.69 ± 3.69) months,and that of the patients in the control group was(18.65 ± 1.25) months,with the significant difference between the two groups(P 0.01). Cumulative recurrence rate of the patients in treatment group was significantly lower than that of the patients in the control group. At the same time,the cumulative survival rate was significantly higher than that in the control group,with the significant difference between the two groups(P 0.01). Conclusion Alareilin could improve the clinical curative effect of patients with OEC undergoing laparoscopic cyst,and prolong the time of recurrence,reduce the recurrence rate,which has the important value of prevention on recurrence of OEC.