Novel injectable sodium alginate hydrogel developed for improved endometrial repair with human umbilical cord mesenchymal stem cells

Yifan Li, Weimin Yin, Haiqing Dong, Rongxiang Wang, Lihua Sun, Yongyong Li, Jing Xie
In: Drug Delivery and Translational Research · 2025 · vol. 15(12) , pp. 4638–4653 · doi:10.1007/s13346-025-01846-4 · PMID:40195258 · W4409271529
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

An injectable RGD-modified sodium alginate hydrogel with calcium gluconate crosslinking enhanced human umbilical cord mesenchymal stem cell delivery for improved endometrial repair in a mouse model.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The study developed a novel injectable sodium alginate hydrogel for endometrial regeneration by encapsulating human umbilical cord mesenchymal stem cells (UCMSCs). The authors used calcium gluconate crosslinking to improve hydrogel homogeneity and injectability versus calcium chloride, and modified the scaffold with RGD to enhance UCMSC adhesion, proliferation, and differentiation in vitro. In a mouse model of endometrial injury, intrauterine transplantation of RGD-modified UCMSC-loaded hydrogel improved endometrial thickness, reduced fibrosis, increased angiogenesis, and raised pregnancy rates compared with untreated controls and UCMSCs alone. The paper does not report data availability and indicates raw/processed data cannot be shared due to technical or time limitations. This paper is centrally about endometriosis—specifically endometrial repair using an injectable UCMSC hydrogel aimed at treating endometrial damage that is relevant to endometriosis-associated tissue dysfunction.

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last seen: 2026-06-10T17:14:06.276822+00:00
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