PENGARUH PEMBERIAN EKSTRAK ETANOL KULIT BUAH NAGA \nMERAH (HYLOCEREUS POLYRHIZUS) BERBAGAI DOSIS TERHADAP \nKADAR INTERLEUKIN-6, EKSPRESI CASPASE-3, DAN JUMLAH \nAPOPTOSIS SEL GRANULOSA \nPenelitian Eksperimental Pada Hewan Coba Mencit Model Endometriosis

One of the infertility mechanisms associated with endometriosis is the \nimmune response in peritoneal zalir in the form of increased macrophages and \nexcessive secretion of some cytotine such as IL-6 which binds to its receptors \nleading to activation of NF-KB in granulose cells inducing genes involved in \ninflammatory and apoptotic responses. The secretion of the cytokine is inhibited by \npreventing the activation of NF-KB using the extract of red dragon fruit peel. This \nresearch is aimed at studying the effect ethanol extract taken from red dragon fruit \npeel with doses of 0.25; 0.5; and 1mg/g Body weight to IL-6 concentration, caspase \n3 expression and number of apoptotic granulose cell in endometriosis mice model. \nThe sample consisting of 30 female mice were devided into 5 for each groups. The \ngroups were of negative group, positive group, and graded dose treatment group. \nPositive control and treatment were endometriosis for 14 days, the next 14 days \nnegative and positive group were given 0.5% Na-CMC solution, while treatment \ngroup was given graded doses. This type research is true experimental using the \nrandomized post test only control group experimental. The results of this research \nsignificant differences in IL-6 concentration, caspase-3 expression, and number of \napoptotic granulose cell in the control and treatment groups. Extract of hylocereus \npolyrhizus peel on endometriosis mice can suppress IL-6 concentration, caspase-3 \nexpression, and number of apoptotic granulose cell with p<0.05 significanse