Screening for asymptomatic mpox in at-risk populations: A cross-sectional study

Screening for asymptomatic mpox in at-risk populations: A cross-sectional study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 11 February 2025 V1 Latest version Share on Screening for asymptomatic mpox in at-risk populations: A cross-sectional study Authors : Inés Armenteros-Yeguas 0009-0006-2435-1368 [email protected] , Reynaldo Homen 0000-0002-2307-5078 , Adrián Valls , Laura Dans , Eva Orviz , Oskar Ayerdi , Teresa Puerta , … Show All … , Mar Vera , Jorge Alfredo Pérez-García , Montserrat Torres , Mayte Coiras , Jorge DEL ROMERO , and Vicente Estrada 0000-0002-7795-5986 Show Fewer Authors Info & Affiliations https://doi.org/10.22541/au.173927163.33062076/v1 Published PLOS One Version of record Peer review timeline 252 views 134 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: Mpox is a viral disease caused by an orthopoxvirus called monkeypox virus. It experienced a significant increase in cases in 2022 worldwide, mostly with sexual transmission. The possibility of hidden circulation of this infection among asymptomatic individuals remains unclear. Methods: This is a multi-centre, observational cross-sectional study conducted in a sexually transmitted infections (STIs) clinic in its referral hospital between July and October 2023 in Madrid, Spain. Pharyngeal and rectal swab samples were collected from each participant and processed to detect bacterial STIs and mpox. Socio-demographic, clinical and behavioural data were collected and a descriptive analysis was performed. Results: A total of 343 asymptomatic participants were included. The prevalence of asymptomatic mpox infection was 0.3% (n=1) and the only positive case developed symptoms shortly after sampling, ruling out a fully asymptomatic infection. The percentage of vaccinated individuals was 36.1%. 13.2% had previously contracted mpox. Other STIs were detected in 21.6% of participants. Conclusions: Although there is an asymptomatic period before symptoms in which individuals could transmit mpox infection, testing for asymptomatic individuals at risk of STIs is not a cost-effective approach. Additionally, the ongoing cases of mpox in Spain are likely not related to the presence of asymptomatic carriers. Supplementary Material File (armenteros-yeguas et al 2025 (09.feb).docx) Download 71.82 KB Information & Authors Information Version history V1 Version 1 11 February 2025 Peer review timeline Published PLOS One Version of Record 30 Oct 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords epidemiology immunity/immunization poxvirus sexually transmitted disease virus classification Authors Affiliations Inés Armenteros-Yeguas 0009-0006-2435-1368 [email protected] Centro Sanitario Sandoval View all articles by this author Reynaldo Homen 0000-0002-2307-5078 Instituto de Investigacion Sanitaria Hospital Clinico San Carlos View all articles by this author Adrián Valls Instituto de Investigacion Sanitaria Hospital Clinico San Carlos View all articles by this author Laura Dans Centro Sanitario Sandoval View all articles by this author Eva Orviz Centro Sanitario Sandoval View all articles by this author Oskar Ayerdi Centro Sanitario Sandoval View all articles by this author Teresa Puerta Centro Sanitario Sandoval View all articles by this author Mar Vera Centro Sanitario Sandoval View all articles by this author Jorge Alfredo Pérez-García Centro Sanitario Sandoval View all articles by this author Montserrat Torres Centro de Investigacion Biomedica en Red Enfermedades Infecciosas View all articles by this author Mayte Coiras Centro de Investigacion Biomedica en Red Enfermedades Infecciosas View all articles by this author Jorge DEL ROMERO Centro Sanitario Sandoval View all articles by this author Vicente Estrada 0000-0002-7795-5986 Instituto de Investigacion Sanitaria Hospital Clinico San Carlos View all articles by this author Metrics & Citations Metrics Article Usage 252 views 134 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Inés Armenteros-Yeguas, Reynaldo Homen, Adrián Valls, et al. Screening for asymptomatic mpox in at-risk populations: A cross-sectional study. Authorea . 11 February 2025. DOI: https://doi.org/10.22541/au.173927163.33062076/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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