Demonstration of neuroendocrine cells in ovarian mucinous tumors.

Sasaki E, Sasano N, Kimura N, Andoh N, Yajima A
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 1989 · doi:10.1097/00004347-198909000-00002 · PMID:2570045
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Immunohistochemical analysis of ovarian mucinous tumors reveals that borderline tumors exhibit a significantly higher frequency and multiplicity of neuroendocrine cells compared to other mucinous or non-mucinous ovarian carcinomas.

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This study investigated the presence and frequency of neuroendocrine cells within various types of ovarian mucinous tumors, including cystadenocarcinomas, borderline tumors, and cystadenomas. Researchers utilized argyrophil staining and immunohistochemistry to detect multiple neurohormones such as serotonin, somatostatin, and gastrin across different tumor subtypes. The findings revealed that borderline mucinous tumors exhibited a significantly higher frequency of these cells compared to clear cell carcinomas, serous cystadenocarcinomas, and metastatic carcinases, suggesting their unique endocrine profile within the spectrum of mucinous ovarian neoplasms. Relevance to endometriosis: This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The frequency of argyrophil cells in mucinous cystadenocarcinomas, borderline tumors (MBT) and cystadenomas was 29.8% (14 of 47), 46.7% (7 of 15) and 11.1% (2 of 18), respectively. These were statistically higher than the frequencies in 17 clear cell carcinomas, 43 serous cystadenocarcinomas, and 24 metastatic carcinomas. Immunoreactive cells for serotonin, somatostatin, gastrin, pancreatic polypeptide, growth hormone-releasing hormone, metenkephalin, neuron-specific enolase, and chromogranin-A were detected in almost all these cases with argyrophil cells. However, immunoreactivities for glucagon, vasoactive intestinal polypeptide, and adrenocorticotropic hormone were negative in ovarian mucinous tumors. Immunohistochemical multiplicity of neurohormones was remarkable in 15 MBT (including 5 müllerian and 10 intestinal MBT) and it was not related to the number of argyrophil cells per unit tumor cells. Individual hormones demonstrated here seemed to be present in different cells, but certain cells were immunoreactive for both gastrin and somatostatin by double immunostaining. Based on the high frequency of endocrine cells, borderline tumors seemed to be unique in the spectrum of mucinous ovarian tumors.
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Demonstration of Neuroendocrine Cells in Ovarian Mucinous Tumors - Etsuko Sasaki - Nobuaki Sasano - Noriko Kimura - Noriaki Andoh - Akira Yajima The frequency of argyrophil cells in mucinous cystadenocarcino-mas, borderline tumors (MBT) and cystadenomas was 29.8% (14 of 47), 46.7% (7 of 15) and 11.1% (2 of 18), respectively. These were statistically higher than the frequencies in 17 clear cell carcinomas, 43 serous cystadenocarcinomas, and 24 metastatic carcinomas. Immunoreactive cells for serotonin, somatostat-in, gastrin, pancreatic polypeptide, growth hormone-releasing hormone, met-enkephalin, neuron-specific enolase, and chromogranin-A were detected in almost all these cases with argyrophil cells. However, immunoreactivities for glucagon, vasoactive intestinal polypeptide, and adrenocorticotropic hormone were negative in ovarian mucinous tumors. Immunohistochemical multiplicity of neurohormones was remarkable in 15 MBT (including 5 müllerian and 10 intestinal MBT) and it was not related to the number of argyrophil cells per unit tumor cells. Individual hormones demonstrated here seemed to be present in different cells, but certain cells were immunoreactive for both gastrin and somatostatin by double immunostaining. Based on the high frequency of endocrine cells, borderline tumors seemed to be unique in the spectrum of mucinous ovarian tumors.

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