THERMOPHOTOBIOMODULATION OF STEM CELLS

The effect of thermophotobiomodulation (TPBM) was demonstrated, which leads to a significant increase in the proliferation rate of bone marrow mesenchymal stem cells (MSCs) of rats due to the combined effect of moderate heating and laser radiation with a wavelength of λ=980 nm. With the help of special digital processing methods, it was found that such an effect, with optimal parameters of TPBM, leads to an increase in the number of colonies by 4.1 ± 0.5 times, and the total number of cells in colonies by 3.3 ± 0.4 times compared with the control. It has been shown that such an increase in the number of cells occurs due to an increase in the number of colonies formed, which is associated with a laser-stimulated increase in cell migration activity. Such activation of MSCs is the most important task of cell transplantology and regenerative medicine.