Impact of Semaglutide Exposure on Neonatal Outcomes in Pregnant Women: A Systematic Review

Impact of Semaglutide Exposure on Neonatal Outcomes in Pregnant Women: A Systematic Review | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 18 June 2025 V1 Latest version Share on Impact of Semaglutide Exposure on Neonatal Outcomes in Pregnant Women: A Systematic Review Authors : Laura Mandal Hauge Hansen , Louise Udby Andersen 0009-0004-0294-0562 [email protected] , Mette Tanvig , Birgitte Møller Luef , and Christina Vinter Authors Info & Affiliations https://doi.org/10.22541/au.175023393.36965849/v1 370 views 142 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background : Semaglutide, a glucagon-like peptide-1 receptor agonist, is increasingly used for obesity and type 2 diabetes treatment. As its use rises among women of reproductive age, understanding its impact on neonatal health is essential. Objectives : To assess neonatal outcomes associated with semaglutide exposure during pregnancy or within two months before conception. Search Strategy : PubMed, Embase, and ClinicalTrials.gov were searched for relevant studies. Selection Criteria : Studies reporting neonatal outcomes following semaglutide exposure before or during pregnancy were included, with no language restrictions. Data Collection and Analysis : Two reviewers independently screened and extracted data. Due to study heterogeneity, a narrative synthesis was used, and bias risk and study quality were assessed. Main Results : Five studies involving a total of 1,128 semaglutide exposed pregnancies, showed mixed results. One study reported adverse outcomes including spontaneous abortion and preeclampsia. Another study found spontaneous abortion rate of 23%, comparable to diabetes- and obesity-groups. A third study observed a prevalence of congenital malformations of 8.3%, with no significant risk increase compared to insulin. One study linked semaglutide discontinuation to foetal macrosomia and neonatal hypoglycaemia. Another noted preterm birth and large-for-gestational-age infants, with no increased congenital malformation risk. No clear association with birth defects was identified, however the evidence is limited by study variability and bias risk. Conclusions : The limited number of available studies precludes firm conclusions nevertheless current evidence does not indicate a consistent increased risk of major congenital malformations associated with semaglutide exposure. Supplementary Material File (main document bjog.docx) Download 123.86 KB File (table 1.docx) Download 17.62 KB File (table 2.docx) Download 139.14 KB File (table 3.docx) Download 270.71 KB Information & Authors Information Version history V1 Version 1 18 June 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords diabetes in pregnancy infertility: basic science maternal medicine miscarriage paediatrics: neonatal systematic reviews Authors Affiliations Laura Mandal Hauge Hansen Syddansk Universitet Klinisk Institut View all articles by this author Louise Udby Andersen 0009-0004-0294-0562 [email protected] Syddansk Universitet Klinisk Institut View all articles by this author Mette Tanvig Odense Universitetshospital View all articles by this author Birgitte Møller Luef Syddansk Universitet Klinisk Institut View all articles by this author Christina Vinter Syddansk Universitet Klinisk Institut View all articles by this author Metrics & Citations Metrics Article Usage 370 views 142 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Laura Mandal Hauge Hansen, Louise Udby Andersen, Mette Tanvig, et al. Impact of Semaglutide Exposure on Neonatal Outcomes in Pregnant Women: A Systematic Review. Authorea . 18 June 2025. DOI: https://doi.org/10.22541/au.175023393.36965849/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.175023393.36965849/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'a00db8053b2ddf88',t:'MTc3OTY0MDU4MQ=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();