The Influence of HuPoSan on MMP-2 and TIMP-2 Endometriosis Rats

Objective:Based on the molecular biology method,from MMP-2,TIMP-2 perspectives to explore mechanism of HuPoSan therapy for endometriosis.Methods: 50 SD rats were divided into the blank group,pseudo surgery group,disease model group,HuPoSan group,danazol group.Results:1.After self intima implantation,the MMP-2 and TIMP-2 contents in Reign and ectopic endometrial of EMs rats were higher than those of pseudo surgical group 2.The MMP-2 content in ectopic of EMs had the same level with normal group,TIMP-2 was obviously higher than that of normal group,the difference was significant(P0.01) 3.After the treatment of HuPoSan,the contents of MMP-2 and TIMP-2 in EMs rats ectopic endometrial were significantly lower,and their difference was significant(P0.01).Conclusion: In the ectopic endometrial of disease model group has the phenomenon of MMP-2 high expression,and compared with normal group there is a significant difference(P0.01).In the disease group TIMP-2 expression increases in reign and ectopic endometrial,and compared with the normal group there is a significant difference(P0.01).