HPV induced ovarian squamous cell carcinoma: case report and review of the literature

Background Ovarian squamous cell carcinoma is usually derived from a teratoma, a Brenner tumour or endometriosis. Association with an HPV infection is rare. Case A fourth case of ovarian squamous cell cancer associated with HR-HPV is presented. Debulking for stage IIIc ovarian squamous cell cancer was performed and she received adjuvant combination chemotherapy. She developed bone metastases and received radiotherapy. The Progression of these metastases and the newly developed metastases did not respond to an oral tyrosine kinase inhibitor (gefitinib).

The development of bone metastases in association with an ovarian squamous cell carcinoma is a rare finding, and it did not respond to treatment with a tyrosine kinase. A review of literature is presented. Similar content being viewed by others

zur Hausen H (1991) Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184(1):9–13 Krumerman MS, Chung A (1977) Squamous carcinoma arising in benign cystic teratoma of the ovary: a report of four cases and review of the literature. Cancer 39(3):1237–1242 Idelson MG (1963) Malignancy in Brenner tumors of the ovary, with comments on histogenesis and possible estrogen production. Obstet Gynecol Surv 18:246–267 Lele SB, Piver MS, Barlow JJ, Tsukada Y (1978) Squamous cell carcinoma arising in ovarian endometriosis. Gynaecol. Oncol 6:290–293 Mai KT, Yazdi HM, Bertrand MA, LeSaux N, Cathcart LL (1996) Bilateral primary ovarian squamous cell carcinoma associated with human papilloma virus infection and vulvar and cervical intraepithelial neoplasia. A case report with review of the literature. Am J Surg Pathol 20(6):767–772 Pins MR, Young RH, Crum CP, Leach IH, Scully RE (1997) Cervical squamous cell carcinoma in situ with intraepithelial extension to the upper genital tract and invasion of tubes and ovaries: report of a case with human papilloma virus analysis. Int J Gynecol Pathol 16(3):272–278 Manolitsas TP, Lanham SA, Hitchcock A, Watson RH (1998) Synchronous ovarian and cervical squamous intraepithelial neoplasia: an analysis of HPV status. Gynecol Oncol 70(3):428–431 Black WC, Benites RE (1964) Nonteratomatous squamous cell carcinoma in situ of the ovary. Obstet Gynecol 24:865–868 Shingleton HM, Middleton FF, Gore H (1974) Squamous cell carcinoma in the ovary. Am J Obstet Gynecol 120(4):556–560 Gendary R, Parmly T, Woodruff JD (1979) Simultaneous malignant squamous metaplasia of the cervix and ovary. Gynecol Oncol 8:97–91 Macko MB, Johnson LA (1983) Primary squamous ovarian carcinoma. A case report and review of literature. Cancer 52:1117–1119 Ben-Baruch G, Menashe Y, Herczeg E, Menczer J (1988) Pure primary ovarian squamous cell carcinoma. Gynecol Onco 29(2):257–262 Yetman TJ, Dudzinski MR (1989 ) Primary squamous carcinoma of the ovary: a case report and review of the literature. Gynecol Oncol 34(2):240–243 Radhi JM, Awad SM (1990) Bilateral squamous cell carcinoma of the ovary. Case report. Br J Obstet Gynaecol 97(9):855–856 McGrady BJ, Sloan JM, Lamki H, Fox H (1993) Bilateral ovarian cysts with squamous intraepithelial neoplasia. Int J Gynecol Pathol 12(4):350–354 Sworn MJ, Jones H, Letchworth AT, Herrington CS, McGee JO (1995) Squamous intraepithelial neoplasia in an ovarian cyst, cervical intraepithelial neoplasia, and human papillomavirus. Hum Pathol 26(3):344–347 Henriksen E (1949) Lymphatic spread of cervix and corpus carcinoma. Am J Obstet Gynaecol 58:924 Cormio G, Rossi C, Cazzolla A, Resta L, Loverro G et al (2003) Distant metastases in ovarian carcinoma. Int J Gynecol Cancer 13(2):125–129 Eltabbakh GH, Hempling RE, Recio FO, O’Neill CP (1998) Remarkable response of primary squamous cell carcinoma of the ovary to paclitaxel and cisplatin. Obstet Gynecol 91(5 Pt 2):844–846 Ohtani K, Sakamoto H, Masaoka N, Shimada K, Kanaeda T, Kurihara M, Nagai N, Satoh KA (2000) case of rapidly growing ovarian squamous cell carcinoma successfully controlled by weekly paclitaxel-carboplatin administration. Gynecol Oncol 79(3):515–518 Trimbos JB, Vergote I, Bolis G, Vermorken JB, Mangioni et al (2003) Impact of adjuvant chemotherapy and surgical staging in early-stage ovarian carcinoma: european organisation for research and treatment of cancer-adjuvant chemotherapy in ovarian neoplasm trial. J Natl Cancer Inst 95(2):113–125 Yarden Y (2001) The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities. Eur J Cancer 37(Suppl 4):S3–S8 Barnes CJ, Bagheri-Yarmand R, Mandal M, Yang Z, Clayman GL et al (2003) Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa). Molr Cancer Therapeut 2:345–351 Harari PM (2004) Epidermal growth factor receptor inhibition strategies in oncology. Endocrine Related Cancer 11:689–708 Tagliaferri P, Tassone P, Blotta S, Viscomi C, Grillone F et al (2005) Antitumor therapeutic strategies based on the targeting of epidermal growth factor-induced survival pathways. Curr Drug Targets 6(3):289–300 Dancey JE, Freidlin B (2003) Targeting epidermal growth factor receptor—are we missing the mark? Lancet 362:62–64 Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Verguts, J., Amant, F., Moerman, P. et al. HPV induced ovarian squamous cell carcinoma: case report and review of the literature. Arch Gynecol Obstet 276, 285–289 (2007). https://doi.org/10.1007/s00404-007-0333-5 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00404-007-0333-5