MENSTRUAL RESPONSE TO LUTEINIZING EXTRACT OF PREGNANCY URINE

Hamblen (1), Novak and Hurd (2) and others describe beneficial changes in menstrual irregularities following the hypodermic injection of a luteinizing extract of pregnancy urine (Antuitrin-S, Parke, Davis & Co.).* Search of the literature revealed no observations on its effect upon normal menstruation. The present brief report deals with this relationship. A group of 10 normal women volunteered as subjects for study. Of these, only one was married. Five were medical students and four were studying physical education. Seven were in the third and two were in the fourth decades of life. The married subject was in the fifth decade. The average weight of the ten subjects was 135 pounds and their average height 5 feet 4 inches. The luteinizing extract of pregnancy urine assayed at approximately 100 rat units per cubic centimeter. The subjects received 10 injections. The first dose was 1 cc. and subsequent ones 2 cc, if this amount did not create too much local reaction. In that case a smaller dose was given. The injections were given daily, except Sunday. The total dosage varied from 12 to 20 cc, the average being 17.5 cc