Trends of uterine cancer burden in 204 countries and regions from 2000 to 2019 and disease burden prediction

Abstract Background: Uterine cancer is the most common gynecological malignancy and the fourth most common cancer in women. However, the global burden of uterine cancer has not been estimated, and projections of future disease development are lacking. Methods: Methods: We collected detailed information on the etiology of uterine cancer between 2000 and 2019 from the 2019 Global Burden of Disease Study. Estimated annual percentage changes (EAPCs) of age-standardized incidence rates (ASR) of uterine cancer by region and etiology were calculated to quantify temporal trends in uterine cancer ASR. Predicting future trends in uterine cancer using the EAPC package. Results: Globally, uterine cancer cases increased from 244,441 in 2000 to 435,041 in 2019, an increase of 78%. During this period, overall ASR increased by an average of 4% per year. The most pronounced increases are usually seen in countries with high sociodemographic indices, such as the United States. The high body-mass index had a significant effect on disability-adjusted life years(DALYs), Deaths, years lived with disability(YLDs), and years of life lost(YLL)s, and 40.2% of DALYs, 39.8% of Deaths, 43.5% of YLDs, and 39.8% of YLLs were attributed to the high body-mass index. EAPC was significantly correlated with ASR (2000) and Human Development Index (HDI) (2019), respectively. Using BAPC models to predict future uterine cancer incidence will continue to rise Conclusion: The number of uterine cancer cases is on the rise globally. Overall, we observed a higher incidence trend in countries with higher socio-demographic index. High body-mass index is an important risk factor for uterine cancer. This suggests that current prevention strategies should be repositioned and, in some countries, more targeted and specific strategies should be developed to prevent the increase in uterine cancer.