Preterm Birth Is Associated With Reduced Risk of Atopic Dermatitis and Allergic Comorbidity in Early Childhood

Preterm Birth Is Associated With Reduced Risk of Atopic Dermatitis and Allergic Comorbidity in Early Childhood | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 17 June 2025 V1 Latest version Share on Preterm Birth Is Associated With Reduced Risk of Atopic Dermatitis and Allergic Comorbidity in Early Childhood Authors : Iben Frier-Ruge 0000-0003-3914-360X , Mia-Louise Nielsen , Anne-Sofie Halling 0000-0003-0166-6560 , Trine Gerner 0000-0002-5377-4013 , Maria Rinnov , Simon Trautner , Simon Francis Thomsen , … Show All … , Lone Skov , Alexander Egeberg , Ivone Jakasa , Sanja Kezic , Alan Irvine 0000-0002-9048-2044 , Emma Guttman-Yassky 0000-0002-9363-324X , Klaus Bønnelykke , and Jacob Thyssen 0000-0003-3770-1743 [email protected] Show Fewer Authors Info & Affiliations https://doi.org/10.22541/au.175017975.58591412/v1 383 views 214 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background Pediatric atopic dermatitis (AD) is closely linked to the subsequent development of food allergy, asthma, and rhinitis. It is currently unknown if the association is influenced by birth maturity. Objectives To investigate the occurrence of AD, food allergy, asthma, and rhinitis in term and preterm children from birth to age 4-5 years. Methods A prospective birth cohort of 389 children (261 term, 128 preterm) was followed from birth to 4–5 years. Results The overall prevalence of AD was 29.6% at age 2 years and 33.0% at 4-5 years. Preterm children had a lower prevalence of AD (19.2% vs. 39.8%, p < 0.0001), later AD onset (median 12.0 vs. 7.5 months, p < 0.01), milder disease severity (median EASI 1.4 vs. 4.8, p < 0.01), and less persistent AD (11.5% vs. 19.9%, p < 0.0001) than term children. Among children born preterm and term, the prevalence of food allergy, asthma, and rhinitis at ages 4-5 years was 1.6% vs. 3.1%, 20.0% vs. 13.0%, and 6.2% vs. 4.6%, respectively. No preterm children with AD (n=25) developed food allergies within 4–5 years compared to 6.7% among term born children, whereas asthma prevalence was higher among preterm children with AD (36.0%) compared to term children with AD (17.3%) (p=0.05). Conclusion Prematurely born children have a conspicuously reduced risk of AD, with later onset and a milder and less persistent disease course. Prematurely born children had significantly different epidemiology of food allergy and asthma compared to term born children. Supplementary Material File (preterm birth is associated with reduced risk of atopic dermatitis and allergic comorbidity in early childhood_submission.docx) Download 805.13 KB Information & Authors Information Version history V1 Version 1 17 June 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords asthma atopic dermatitis food allergy pediatrics rhinitis Authors Affiliations Iben Frier-Ruge 0000-0003-3914-360X Bispebjerg Hospital View all articles by this author Mia-Louise Nielsen Bispebjerg Hospital View all articles by this author Anne-Sofie Halling 0000-0003-0166-6560 Bispebjerg Hospital View all articles by this author Trine Gerner 0000-0002-5377-4013 Gentofte Hospital Hud og allergiafdeling View all articles by this author Maria Rinnov Gentofte Hospital Hud og allergiafdeling View all articles by this author Simon Trautner Rigshospitalet View all articles by this author Simon Francis Thomsen Bispebjerg Hospital View all articles by this author Lone Skov Gentofte Hospital Hud og allergiafdeling View all articles by this author Alexander Egeberg Bispebjerg Hospital View all articles by this author Ivone Jakasa University of Zagreb View all articles by this author Sanja Kezic University of Amsterdam View all articles by this author Alan Irvine 0000-0002-9048-2044 Trinity College Dublin Department of Clinical Medicine View all articles by this author Emma Guttman-Yassky 0000-0002-9363-324X Icahn School of Medicine at Mount Sinai Department of Medicine View all articles by this author Klaus Bønnelykke Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Jacob Thyssen 0000-0003-3770-1743 [email protected] Bispebjerg Hospital View all articles by this author Metrics & Citations Metrics Article Usage 383 views 214 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Iben Frier-Ruge, Mia-Louise Nielsen, Anne-Sofie Halling, et al. Preterm Birth Is Associated With Reduced Risk of Atopic Dermatitis and Allergic Comorbidity in Early Childhood. Authorea . 17 June 2025. DOI: https://doi.org/10.22541/au.175017975.58591412/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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