Tacrolimus-induced Reversible Cerebral Vasoconstriction Syndrome after Heart Transplant: Case Report

Abstract We describe the case of a patient with a recurrent severe headache that occurred after heart transplant surgery. She was diagnosed with reversible cerebral vasoconstriction syndrome (RCVS) since typical imaging was seen through brain contrast computed tomography. Tacrolimus, an immunosuppressant, was suspected as the cause of the RCVS. The treatment was switched to cyclosporine, after which there was rapid improvement of her symptoms. This case highlights the importance of an immediate diagnosis to switch immunosuppressants to relieve symptoms and prevent progression to severe neurological dysfunction.