Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan

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However, we present an infant born at 35 weeks of gestation diagnosed with cerebral palsy associated with periventricular leukomalacia (PVL) without fetal heart rate (FHR) monitoring abnormalities, According to the summary reports of PVL cases published on the home page of the Japan Obstetric Compensation System for Cerebral Palsy (JOCSC)), the percentage of placenta previa without FHR monitoring abnormalities in the cases of PVL was 5.7% (12/209), which seemed to be higher than the total percentage of placenta previa reported in Japan (0.3–0.5%)." } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/9-241", "name": "Case Report: Peripartum periventricular leukomalacia resulting in..." } } ] } Home Browse Case Report: Peripartum periventricular leukomalacia resulting in... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Suzuki S. Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.12688/f1000research.22878.5 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Brief Report Revised Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] Previously titled: Placenta previa as a risk factor for antenatal- and peripartum periventricular leukomalacia resulting in cerebral palsy in Japan: a retrospective study Shunji Suzuki https://orcid.org/0000-0002-3996-2624 Shunji Suzuki https://orcid.org/0000-0002-3996-2624 PUBLISHED 06 Aug 2024 Author details Author details Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, Tokyo, 124-0012, Japan Shunji Suzuki Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS Abstract Intrapartum fetal heart rate monitoring abnormalities had been reported to correlate with decreased umbilical artery base excess associated with neonatal seizures. However, we present an infant born at 35 weeks of gestation diagnosed with cerebral palsy associated with periventricular leukomalacia (PVL) without fetal heart rate (FHR) monitoring abnormalities, According to the summary reports of PVL cases published on the home page of the Japan Obstetric Compensation System for Cerebral Palsy (JOCSC)), the percentage of placenta previa without FHR monitoring abnormalities in the cases of PVL was 5.7% (12/209), which seemed to be higher than the total percentage of placenta previa reported in Japan (0.3–0.5%). READ ALL READ LESS Keywords periventricular leukomalacia, placenta previa, Japan Corresponding Author(s) Shunji Suzuki ( [email protected] ) Close Corresponding author: Shunji Suzuki Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2024 Suzuki S. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Suzuki S. Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.12688/f1000research.22878.5 ) First published: 07 Apr 2020, 9 :241 ( https://doi.org/10.12688/f1000research.22878.1 ) Latest published: 06 Aug 2024, 9 :241 ( https://doi.org/10.12688/f1000research.22878.5 ) Revised Amendments from Version 4 I have added the comments to clarify the definitions of moderate and severe decelerations in this study. In addition, I have added the comments in the Discussion with the reviewer's valuable suggestions. I have corrected Table 1. I have added the comments to clarify the definitions of moderate and severe decelerations in this study. In addition, I have added the comments in the Discussion with the reviewer's valuable suggestions. I have corrected Table 1. See the author's detailed response to the review by Yuki Kodama See the author's detailed response to the review by Ambrogio Pietro Londero See the author's detailed response to the review by Euiseok Jung READ REVIEWER RESPONSES Introduction Brain injury in premature infants is generally thought to primarily consist of periventricular leukomalacia (PVL), a distinctive form of cerebral white matter injury. PVL occurs most commonly in premature infants born at less than 32 weeks’ gestation. In an earlier study in Japan, frequent moderate variable deceleration on fetal cardiotocogram (CTG) was observed to be a cause of antenatal PVL in premature infants 1 . In the report by Ito et al. 1 , frequent moderate variable decelerations on fetal CTG were observed frequently for infants with antenatal PVL (80.0%) more frequent than control infants (27.3%, p < 0.05). In addition, in low birth weight infants, intrapartum severe variable deceleration or prolonged deceleration have been suggested to play a causal role in PVL 2 . Although intrapartum fetal heart rate monitoring abnormalities had been reported to correlate with decreased umbilical artery base excess associated with neonatal seizures, recently it has been observed to have no relation to perinatal mortality or pediatric neurologic morbidity 3 , 4 . The main factor related to the presence of PVL has been suggested to be gestational age 4 . We encountered a case of PVL without fetal heart rate monitoring abnormalities. Subsequently, a review and analysis of the summary reports of PVL cases published on the home page (HP) of the Japan Obstetric Compensation System for Cerebral Palsy (JOCSC) was conducted. We conclude that placenta previa may be a risk factor for antenatal- and peripartum PVL resulting in cerebral palsy (CP) in Japan. Case report An elective cesarean section was performed at 35 weeks’ gestation because of placenta previa in the mother with warning bleeding of 60 g. A 2346-g, male infant was delivered with Apgar scores of 8 and 9 at 1 and 5 minutes, respectively. The mother’s pregnancy had progressed uneventfully until the day before the cesarean section. Since 30 weeks’ gestation, she was hospitalized and fetal CTG was monitored every day. There were no moderate/severe decelerations (MSDs) on the CTG. The preoperative fetal CTG, performed 20 minutes before the cesarean section, showed a reassuring fetal status without any fetal heart rate decelerations. The umbilical artery pH was 7.334. The total blood loss during cesarean section was 1,080 g. The infant had no problems during his neonatal period; however, he was diagnosed with CP associated with PVL at the age of 2. Review and analysis of PVL cases on JOCSC To re-examine the previous findings in Japan regarding PVL cases 1 , 2 , we reviewed the summary reports of antenatal- and peripartum PVL cases published on the HP of the JOCSC launched in 2009 5 . This is a free to access resource, and the cause analysis reports (summary reports) of the patients can be accessed here: http://www.sanka-hp.jcqhc.or.jp/documents/analysis/index.html . Those eligible for inclusion in the compensation scheme are infants born between 2009 and 2014 with a birth weight of ≥ 2,000 g, gestation of ≥ 33 weeks and infants born between 2015 and 2019 with a birth weight of ≥ 1,400 g, gestation of ≥ 32 weeks, and severe disability due to CP independent of congenital causes or factors during the neonatal period or later. In the current study, we searched all summary reports published by the end of March 2020 using the keyword ‘PVL’. We have excluded the cases of PVL identified as neonatal cause, such as late circulatory collapse, birth injury, and multiple pregnancies, from the analysis. The following variables were extracted from the reports:fetal heart rate decelerations, intrauterine infection, placental abruption and placenta previa. In this study, the fetal heart pattern was categorized according to the three-tier FHR system by Macones et al . 6 , and no MSDs mean reassuring fetal status without late or variable decelerations, decreased baseline variability, or tachycardia. Data are presented as number (%). SPSS Statistics software version 20 (IBM Csorp., Armonk, NY, USA) was used for statistical analyses. For statistical analysis, the Χ 2 test was used for the categorical variables between cases with and without fetal heart rate decelerations. Differences with p < 0.05 were considered significant. Findings There were 209 cases of PVL published in the HP of JOCSC retrieved in January 2020. In the current examination, 13 cases of monochorionic twins and 9 cases of postnatal PVL due to late circulatory collapse (n = 6), neonatal hypoglycemia (n = 2) and neonatal hyperkalemia (n = 1) were excluded. We examined the presence or absence of MSDs on fetal CTG in the remaining 187 cases. Table 1 shows the clinical characteristics of the 187 cases of antenatal- and peripartum PVL with and without MSDs on fetal CTG. The incidence of neonatal asphyxia in the cases with MSDs was higher than in those without MSDs ( p < 0.01); however, the percentage of cases without MSDs was higher than those with MSDs (73.3 vs. 26.7%, p < 0.01). In cases without MSDs, the percentage of neonates born at term was higher than those with MSDs ( p = 0.04). These cases might have potentially transient episodes leading to PVL in the uterus between 26 and 32 weeks of gestation. Our case may be same as these cases. Table 1. Clinical characteristics of antenatal- and peripartum periventricular leukomalacia with and without moderate/severe decelerations on fetal cardiotocogram. Moderate/severe decelerations, n (%) P -value Odds ratio 95% Confidence Interval (+) (-) Total 50 137 Gestational age at delivery (weeks) < 30 12 (24.0) 29 (21.2) 0.15 0.471 0.18-1.2 30–31 14 (28.0) 26 (19.0) 0.22 0.512 0.19-1.4 32–33 15 (30.0) 33 (24.1) 0.46 0.607 0.23-1.6 34–36 8 (16.0) 29 (21.2) Ref. 1 - ≥ 37 0 (0) 20 (14.6) 0.04 Inf. 1.3-Inf. Cesarean delivery No 21 (42.0) 52 (38.0) Ref. 1 - Yes 29 (58.0) 85 (62.0) 0.62 1.19 0.62-2.3 Apgar score at 1 min < 4 22 (44.0) 27 (19.7) < 0.01 0.223 0.098-0.51 4–6 16 (32.0) 44 (32.1) 0.14 0.500 0.22-1.1 ≥ 7 12 (24.0) 66 (48.2) Ref. 1 - Umbilical artery pH ≥ 7.0 34 (68.0) 115 (99.1) Ref. 1 - < 7.0 11 (22.0) 1 (0.9) < 0.01 0.0270 0.004-0.17 Fetal growth restriction No 41 (82.0) 117 (85.4) Ref. 1 - Yes 9 (18.0) 20 (14.6) 0.65 0.779 0.33-1.8 Table 2 shows the perinatal complications in the cases of antenatal- and peripartum PVL with and without MSDs on fetal CTG. The incidence of intrauterine infection and placental abruption in the cases with MSDs was higher than those without MSDs ( p < 0.01), while the incidence of placenta previa in the cases without MSDs was higher than those with MSDs ( p = 0.04). The former results were as expected, while the latter may be a new finding. The percentage of placenta previa in the cases of PVL was 5.7% (12/209), which seemed to be higher than the total percentage of placenta previa reported in Japan (0.3-0.5%) 7 . Table 2. Perinatal complications in the cases of antenatal- and peripartum periventricular leukomalacia with and without moderate/severe decelerations on fetal cardiotocogram. Moderate/severe decelerations, n (%) P -value Odds ratio 95% Confidence Interval (+) (-) Total 50 137 Perinatal complications Intrauterine infection 19 (38.0) 22 (16.1) < 0.01 0.312 0.15-0.64 Placental abruption 8 (16.0) 3 (12.2) < 0.01 0.118 0.032-9.4 Placenta previa 0 (0) 12 (8.8) 0.04 Inf. 1.2-Inf. Discussion We present a case of placenta previa without MSDs on fetal CTG resulted in cerebral palsy due to PVL. To date, some possible mechanisms leading to PVL in cases of placenta previa has been discussed in Japan 8 , 9 . Oda et al. 8 reported that the main risk factor for PVL in preterm placenta previa is an initial antepartum hemorrhage <28 weeks of gestation and they speculated that decreased placental perfusion in the second trimester of pregnancy is associated with the developmental window of vulnerability for PVL. However, Furuta et al. 9 observed that acute and massive bleeding from placenta previa at around 30 weeks of gestation is a risk factor for PVL and CP requiring careful neonatal follow-up. However, in the 12 cases of placenta previa in that study, massive bleeding and initial bleeding < 28 weeks of gestation were observed in only 4 (33.3%) and 1 cases (8.3%) Kumazaki et al. 10 observed that gross lesions with disturbance of uteroplacental circulation including massive retroplacental hematoma, extensive infarction or thrombosis, and marked basal or perivillous fibrin deposition frequently in placentae in cases of antenatal- and peripartum PVL. They also observed the high frequency of ischemic changes in villi in those placentae. They reported that intrauterine infection such as chorioamnionitis alone may be insufficient to cause white matter injury whereas circulatory disturbance may be capable of causing the injury by itself. The same findings have been reported to be observed in cases of placenta previa 11 . The same findings may have occurred in the current case. The disturbance of uteroplacental circulation which consists of maternal and fetal blood flow to or through the placenta may be able to occur with a small amount of maternal hemorrhage that does not affect fetal heart rate from the placenta as seen in the current case with placenta previa and it may be associated with the presence of underlie the development of prenatal and peripartum brain injury. Based on the data from JOCSC, serious abnormal fetal heart rate patterns were not observed in approximately 70% of cases with antenatal- and peripartum PVL on fetal CTG, and placenta previa itself may be associated with the development of antenatal- and/or peripartum PVL. The pathophysiology of PVL has been reported to be multifactorial. Hemorrhage due to placental previa could lead to fetal hypoperfusion, which could affect vascular supply of fetal white matter. To date, we do not have accurate tools to evaluate this other than FHR monitoring or ultrasound during pregnancy. A further study of PVL with controls may be needed. Consent Written informed consent for publication of the clinical details of the case report was obtained from the mother in the case report. Data availability Underlying data The Japan Obstetric Compensation System for Cerebral Palsy (JOCSC) for is a free to access resource. Cause analysis reports (summary reports) for patients with periventricular leukomalacia can be accessed here: http://www.sanka-hp.jcqhc.or.jp/documents/analysis/index.html , Feb 12, 2020). These reports are in Japanese. Figshare: Data of PVL in Japan, https://doi.org/10.6084/m9.figshare.12033501.v3 12 . This project contains the following underlying data: Dataset 1. Raw data for gestational age, delivery mode, birth weight, Apgar scores, FHR deceleration, placenta abruption, complications, placenta previa from 187 the cases of periventricular leukomalacia on the home page of the Japan Obstetric Compensation System for Cerebral Palsy (JOCSC: http://www.sanka-hp.jcqhc.or.jp/documents/analysis/index.html , Feb 12, 2020). Data are available under the terms of the Creative Commons Zero “No rights reserved” data waiver (CC0 1.0 Public domain dedication). Faculty Opinions recommended References 1. Ito T, Kadowaki K, Takahashi H, et al. : Clinical features of and cardiotocographic findings for premature infants with antenatal Periventricular Leukomalacia. Early Hum Dev. 1997; 47 (2): 195–201. PubMed Abstract | Publisher Full Text 2. Ibara S, Ikenoue T, Sameshima H, et al. : [The perinatal risk factors and Periventricular Leukomalacia (PVL) in premature infants--relationship between fetal heart rate decelerations and PVL]. No To Hattatsu. 1996; 28 (2): 135–137. PubMed Abstract 3. Graham EM, Petersen SM, Christo DK, et al. : Intrapartum electronic fetal heart rate monitoring and the prevention of perinatal brain injury. Obstet Gynecol. 2006; 108 (3 Pt 1): 656–666. PubMed Abstract | Publisher Full Text 4. Romero-Guzman GJ, Lopez-Munoz F: [Prevalence and risk factors for periventricular leukomalacia in preterm infants. A systematic review]. Rev Neurol. 2017; 65 (2): 57–62. PubMed Abstract 5. Japan Council for Quality Health Care: The Japan Obstetric Compensation System for Cerebral Palsy. 2020. Reference Source 6. Gracia-Perez-Bonfils A, Vigneswaran K, Cuadras D, et al. : Does the saltatory pattern on cardiotocograph (CTG) trace really exist? The ZigZag pattern as an alternative definition and its correlation with perinatal outcomes. J Matern Fetal Neonatal Med . 20019; 1–9. PubMed Abstract | Publisher Full Text 7. Japan Society for Obstetrics and Gynecology: Placenta previa (in Japanese). 2020. Reference Source 8. Oda N, Takeuchi K, Tanaka A, et al. : Obstetric risk factors associated with the development of Periventricular Leukomalacia in preterm infants born to mothers complicated by placenta previa. Fetal Diagn Ther. 2008; 24 (4): 345–348. PubMed Abstract | Publisher Full Text 9. Furuta K, Tokunaga S, Furukawa S, et al. : Acute and massive bleeding from placenta previa and infants' brain damage. Early Hum Dev. 2014; 90 (9): 455–458. PubMed Abstract | Publisher Full Text 10. Kumazaki K, Nakayama M, Sumida Y, et al. : Placental features in preterm infants with Periventricular Leukomalacia. Pediatrics. 2002; 109 (4): 650–655. PubMed Abstract | Publisher Full Text 11. Biswas R, Sawhney H, Dass R, et al. : Histopathological study of placental bed biopsy in placenta previa. Acta Obstet Gynecol Scand. 1999; 78 (3): 173–179. PubMed Abstract | Publisher Full Text 12. Suzuki S: Data of PVL in Japan. figshare. Dataset. 2020. http://www.doi.org/10.6084/m9.figshare.12033501.v3 Comments on this article Comments (0) Version 5 VERSION 5 PUBLISHED 07 Apr 2020 ADD YOUR COMMENT Comment Author details Author details Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, Tokyo, 124-0012, Japan Shunji Suzuki Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (5) version 5 Revised Published: 06 Aug 2024, 9:241 https://doi.org/10.12688/f1000research.22878.5 version 4 Revised Published: 04 Nov 2022, 9:241 https://doi.org/10.12688/f1000research.22878.4 version 3 Revised Published: 25 Aug 2020, 9:241 https://doi.org/10.12688/f1000research.22878.3 version 2 Revised Published: 06 May 2020, 9:241 https://doi.org/10.12688/f1000research.22878.2 version 1 Published: 07 Apr 2020, 9:241 https://doi.org/10.12688/f1000research.22878.1 Copyright © 2024 Suzuki S. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Suzuki S. Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.12688/f1000research.22878.5 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 5 VERSION 5 PUBLISHED 06 Aug 2024 Revised Views 0 Cite How to cite this report: Kodama Y. Reviewer Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.169993.r311512 ) The direct URL for this report is: https://f1000research.com/articles/9-241/v5#referee-response-311512 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 10 Aug 2024 Yuki Kodama , University of Miyazaki, Miyazaki, Japan Approved VIEWS 0 https://doi.org/10.5256/f1000research.169993.r311512 Thank you for the opportunity to review this article ... Continue reading READ ALL Thank you for the opportunity to review this article again. The points which I raised have been properly revised. Competing Interests: No competing interests were disclosed. Reviewer Expertise: Perinatology, Neonatology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Kodama Y. Reviewer Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.169993.r311512 ) The direct URL for this report is: https://f1000research.com/articles/9-241/v5#referee-response-311512 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 13 Aug 2024 Shunji Suzuki , Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan 13 Aug 2024 Author Response Dear Dr. Kodama, Thank you very much for your efforts to improve my manuscript. Sincerely, Shunji Suzuki Competing Interests: N/A Dear Dr. Kodama, Thank you very much for your efforts to improve my manuscript. Sincerely, Shunji Suzuki Dear Dr. Kodama, Thank you very much for your efforts to improve my manuscript. Sincerely, Shunji Suzuki Competing Interests: N/A Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 13 Aug 2024 Shunji Suzuki , Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan 13 Aug 2024 Author Response Dear Dr. Kodama, Thank you very much for your efforts to improve my manuscript. Sincerely, Shunji Suzuki Competing Interests: N/A Dear Dr. Kodama, Thank you very much for your efforts to improve my manuscript. Sincerely, Shunji Suzuki Dear Dr. Kodama, Thank you very much for your efforts to improve my manuscript. Sincerely, Shunji Suzuki Competing Interests: N/A Close Report a concern COMMENT ON THIS REPORT Version 4 VERSION 4 PUBLISHED 04 Nov 2022 Revised Views 0 Cite How to cite this report: Kodama Y. Reviewer Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.140504.r301453 ) The direct URL for this report is: https://f1000research.com/articles/9-241/v4#referee-response-301453 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 01 Aug 2024 Yuki Kodama , University of Miyazaki, Miyazaki, Japan Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.140504.r301453 Thank you for the opportunity to review this article. The author reported a case of PVL in which the antepartum fetal heart rate (FHR) patterns was normal. The 60 g hemorrhage from placental previa was the only antenatal event. ... Continue reading READ ALL Thank you for the opportunity to review this article. The author reported a case of PVL in which the antepartum fetal heart rate (FHR) patterns was normal. The 60 g hemorrhage from placental previa was the only antenatal event. Based on this case, the author investigated PVL cases with and without abnormal FHR patterns in the Japanese cerebral palsy registration database. The point raised by the author is interesting. Since the author has already revised the manuscript several times in response to suggestions from some reviewers, further additional revisions are unlikely. However, I would like to make the following requests. I would like the author to clarify the definitions of moderate and severe decelerations in the analysis of JOCSC database. It is desirable to clarify that no MSDs mean reassuring fetal status without late decelerations, decreased baseline variability, or tachycardia. The pathophysiology of PVL has been reported to be multifactorial, but principally initiated by hypoxia-ischemia and/or systemic inflammation. Hemorrhage due to placental previa could lead to fetal hypoperfusion, which could affect vascular supply of fetal white matter. To date, we do not have accurate tools to evaluate this other than FHR monitoring or ultrasound during pregnancy. Minor comment: (Table 1.) “Urinalysis pH” seems to be “Umbilical artery pH”. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Perinatology, Neonatology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Kodama Y. Reviewer Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.140504.r301453 ) The direct URL for this report is: https://f1000research.com/articles/9-241/v4#referee-response-301453 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Version 3 VERSION 3 PUBLISHED 25 Aug 2020 Revised Views 0 Cite How to cite this report: Jung E. Reviewer Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.28959.r70219 ) The direct URL for this report is: https://f1000research.com/articles/9-241/v3#referee-response-70219 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 01 Sep 2020 Euiseok Jung , Department of Pediatrics, University of Ulsan, Seoul, South Korea Approved VIEWS 0 https://doi.org/10.5256/f1000research.28959.r70219 The author has revised the article at my request. Well worth it to index. However, there is a typing mistake in ... Continue reading READ ALL The author has revised the article at my request. Well worth it to index. However, there is a typing mistake in the Discussion section and correction is required; "They reported that ntrauterine infection ... causing the injury by itself." Competing Interests: No competing interests were disclosed. Reviewer Expertise: Neonatology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Jung E. Reviewer Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.28959.r70219 ) The direct URL for this report is: https://f1000research.com/articles/9-241/v3#referee-response-70219 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 03 Sep 2020 Shunji Suzuki , Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan 03 Sep 2020 Author Response Dear Dr. Euiseok Jung, I would like to thank you for the comments and critique of my manuscript. Sincerely, Shunji Suzuki Competing Interests: No competing Interest. Dear Dr. Euiseok Jung, I would like to thank you for the comments and critique of my manuscript. Sincerely, Shunji Suzuki Dear Dr. Euiseok Jung, I would like to thank you for the comments and critique of my manuscript. Sincerely, Shunji Suzuki Competing Interests: No competing Interest. Close Report a concern Author Response 04 Nov 2022 Shunji Suzuki , Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan 04 Nov 2022 Author Response Dear Professor Euiseok Jung, I am very sorry for the very late reply. Thank you very much for your guidance. I fixed a spelling mistake. Sincerely, Shunji ... Continue reading Dear Professor Euiseok Jung, I am very sorry for the very late reply. Thank you very much for your guidance. I fixed a spelling mistake. Sincerely, Shunji Suzuki Dear Professor Euiseok Jung, I am very sorry for the very late reply. Thank you very much for your guidance. I fixed a spelling mistake. Sincerely, Shunji Suzuki Competing Interests: None. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 03 Sep 2020 Shunji Suzuki , Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan 03 Sep 2020 Author Response Dear Dr. Euiseok Jung, I would like to thank you for the comments and critique of my manuscript. Sincerely, Shunji Suzuki Competing Interests: No competing Interest. Dear Dr. Euiseok Jung, I would like to thank you for the comments and critique of my manuscript. Sincerely, Shunji Suzuki Dear Dr. Euiseok Jung, I would like to thank you for the comments and critique of my manuscript. Sincerely, Shunji Suzuki Competing Interests: No competing Interest. Close Report a concern Author Response 04 Nov 2022 Shunji Suzuki , Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan 04 Nov 2022 Author Response Dear Professor Euiseok Jung, I am very sorry for the very late reply. Thank you very much for your guidance. I fixed a spelling mistake. Sincerely, Shunji ... Continue reading Dear Professor Euiseok Jung, I am very sorry for the very late reply. Thank you very much for your guidance. I fixed a spelling mistake. Sincerely, Shunji Suzuki Dear Professor Euiseok Jung, I am very sorry for the very late reply. Thank you very much for your guidance. I fixed a spelling mistake. Sincerely, Shunji Suzuki Competing Interests: None. Close Report a concern COMMENT ON THIS REPORT Version 2 VERSION 2 PUBLISHED 06 May 2020 Revised Views 0 Cite How to cite this report: Jung E. Reviewer Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.26264.r68656 ) The direct URL for this report is: https://f1000research.com/articles/9-241/v2#referee-response-68656 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 17 Aug 2020 Euiseok Jung , Department of Pediatrics, University of Ulsan, Seoul, South Korea Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.26264.r68656 The authors reported a case of PVL that was attributed to the placenta previa itself, despite the absence of moderate/severe decelerations. Similar cases were analyzed together based on Japanese cerebral palsy registration data. In the ... Continue reading READ ALL The authors reported a case of PVL that was attributed to the placenta previa itself, despite the absence of moderate/severe decelerations. Similar cases were analyzed together based on Japanese cerebral palsy registration data. In the Discussion, previous researches suggested the possible pathophysiology that placenta previa could induce PVL. However, rather than simply listing suggestions from past cases, the author should specifically describe which of these possibilities are more relevant in relation to this case. Please change the author's name of reference #9 to Kumazaki and describe it in Discussion section. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Partly Competing Interests: No competing interests were disclosed. Reviewer Expertise: Neonatology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Jung E. Reviewer Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.26264.r68656 ) The direct URL for this report is: https://f1000research.com/articles/9-241/v2#referee-response-68656 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Version 1 VERSION 1 PUBLISHED 07 Apr 2020 Views 0 Cite How to cite this report: Londero AP. Reviewer Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.25256.r62089 ) The direct URL for this report is: https://f1000research.com/articles/9-241/v1#referee-response-62089 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 27 Apr 2020 Ambrogio Pietro Londero , Clinic of Obstetrics and Gynecology, DAME, ASUI - Presidio Ospedaliero Universitario "SM della Misericordia", University of Udine, Udine, Italy Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.25256.r62089 I read the article by Suzuki S entitled: "Placenta previa as a risk factor for antenatal- and peripartum periventricular leukomalacia resulting in cerebral palsy in Japan: a retrospective study" with interest. The argument is very interesting but ... Continue reading READ ALL I read the article by Suzuki S entitled: "Placenta previa as a risk factor for antenatal- and peripartum periventricular leukomalacia resulting in cerebral palsy in Japan: a retrospective study" with interest. The argument is very interesting but I have some points to highlight in order to improve the manuscript itself: Major issues: The abstract does not reflect in a proper manner the content of the manuscript. In particular, the conclusion in the abstract is a clear overstatement. In fact, the data analyzed in the manuscript do not allow any kind of conclusion about a correlation between placenta previa and neonatal periventricular leukomalacia. In the dataset, only cases of neonatal periventricular leukomalacia without controls are present. For the same reason, the title of the article is also not appropriate, and also the manuscript's main-text itself should be fixed. For the clinical case report, I suggest following the CARE guidelines. Minor issues: A minor issue is that the clarity of the whole manuscript would benefit from a revision of the English language. Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? Partly Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? No Competing Interests: No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Londero AP. Reviewer Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.25256.r62089 ) The direct URL for this report is: https://f1000research.com/articles/9-241/v1#referee-response-62089 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 04 May 2020 Shunji Suzuki , Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan 04 May 2020 Author Response Thank you very much for the comments and critique of my manuscript. I have been able to respond positively to each suggestion and we believe the paper has been strengthened. ... Continue reading Thank you very much for the comments and critique of my manuscript. I have been able to respond positively to each suggestion and we believe the paper has been strengthened. The changes are highlighted with red color. I have re-written the abstract, case report and the title according to your suggestions. In addition, my English has been edited. Thank you very much for your suggestions, again. I do hope and trust that with these changes the manuscript is now acceptable for publication. Thank you for considering my paper. Sincerely yours, Shunji Suzuki, MD Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital 5-11-12-2 Tateishi, Katsushika-ku, Tokyo 124-0012 Japan Tel: +81-3-3693-5211 Fax: +81-3-3694-8725 e-mail: [email protected] Thank you very much for the comments and critique of my manuscript. I have been able to respond positively to each suggestion and we believe the paper has been strengthened. The changes are highlighted with red color. I have re-written the abstract, case report and the title according to your suggestions. In addition, my English has been edited. Thank you very much for your suggestions, again. I do hope and trust that with these changes the manuscript is now acceptable for publication. Thank you for considering my paper. Sincerely yours, Shunji Suzuki, MD Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital 5-11-12-2 Tateishi, Katsushika-ku, Tokyo 124-0012 Japan Tel: +81-3-3693-5211 Fax: +81-3-3694-8725 e-mail: [email protected] Competing Interests: There are no competing interests. Close Report a concern Author Response 04 Nov 2022 Shunji Suzuki , Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan 04 Nov 2022 Author Response Dear Professor Ambrogio Pietro Londero、 Thank you very much for your previous suggestions. I have responded to your questions on May 2020. If you have further suggestions. Please guide ... Continue reading Dear Professor Ambrogio Pietro Londero、 Thank you very much for your previous suggestions. I have responded to your questions on May 2020. If you have further suggestions. Please guide me, again. Sincerely, Shunji Suzuki Dear Professor Ambrogio Pietro Londero、 Thank you very much for your previous suggestions. I have responded to your questions on May 2020. If you have further suggestions. Please guide me, again. Sincerely, Shunji Suzuki Competing Interests: None. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 04 May 2020 Shunji Suzuki , Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan 04 May 2020 Author Response Thank you very much for the comments and critique of my manuscript. I have been able to respond positively to each suggestion and we believe the paper has been strengthened. ... Continue reading Thank you very much for the comments and critique of my manuscript. I have been able to respond positively to each suggestion and we believe the paper has been strengthened. The changes are highlighted with red color. I have re-written the abstract, case report and the title according to your suggestions. In addition, my English has been edited. Thank you very much for your suggestions, again. I do hope and trust that with these changes the manuscript is now acceptable for publication. Thank you for considering my paper. Sincerely yours, Shunji Suzuki, MD Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital 5-11-12-2 Tateishi, Katsushika-ku, Tokyo 124-0012 Japan Tel: +81-3-3693-5211 Fax: +81-3-3694-8725 e-mail: [email protected] Thank you very much for the comments and critique of my manuscript. I have been able to respond positively to each suggestion and we believe the paper has been strengthened. The changes are highlighted with red color. I have re-written the abstract, case report and the title according to your suggestions. In addition, my English has been edited. Thank you very much for your suggestions, again. I do hope and trust that with these changes the manuscript is now acceptable for publication. Thank you for considering my paper. Sincerely yours, Shunji Suzuki, MD Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital 5-11-12-2 Tateishi, Katsushika-ku, Tokyo 124-0012 Japan Tel: +81-3-3693-5211 Fax: +81-3-3694-8725 e-mail: [email protected] Competing Interests: There are no competing interests. Close Report a concern Author Response 04 Nov 2022 Shunji Suzuki , Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan 04 Nov 2022 Author Response Dear Professor Ambrogio Pietro Londero、 Thank you very much for your previous suggestions. I have responded to your questions on May 2020. If you have further suggestions. Please guide ... Continue reading Dear Professor Ambrogio Pietro Londero、 Thank you very much for your previous suggestions. I have responded to your questions on May 2020. If you have further suggestions. Please guide me, again. Sincerely, Shunji Suzuki Dear Professor Ambrogio Pietro Londero、 Thank you very much for your previous suggestions. I have responded to your questions on May 2020. If you have further suggestions. Please guide me, again. Sincerely, Shunji Suzuki Competing Interests: None. Close Report a concern COMMENT ON THIS REPORT Comments on this article Comments (0) Version 5 VERSION 5 PUBLISHED 07 Apr 2020 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 3 Version 5 (revision) 06 Aug 24 read Version 4 (revision) 04 Nov 22 read Version 3 (revision) 25 Aug 20 read Version 2 (revision) 06 May 20 read Version 1 07 Apr 20 read Ambrogio Pietro Londero , University of Udine, Udine, Italy Euiseok Jung , University of Ulsan, Seoul, South Korea Yuki Kodama , University of Miyazaki, Miyazaki, Japan Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Kodama Y. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 10 Aug 2024 | for Version 5 Yuki Kodama , University of Miyazaki, Miyazaki, Japan 0 Views copyright © 2024 Kodama Y. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Thank you for the opportunity to review this article again. The points which I raised have been properly revised. Competing Interests No competing interests were disclosed. Reviewer Expertise Perinatology, Neonatology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (1) Author Response 13 Aug 2024 Shunji Suzuki, Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan Dear Dr. Kodama, Thank you very much for your efforts to improve my manuscript. Sincerely, Shunji Suzuki View more View less Competing Interests N/A reply Respond Report a concern Kodama Y. Peer Review Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.169993.r311512) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/9-241/v5#referee-response-311512 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Kodama Y. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 01 Aug 2024 | for Version 4 Yuki Kodama , University of Miyazaki, Miyazaki, Japan 0 Views copyright © 2024 Kodama Y. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Thank you for the opportunity to review this article. The author reported a case of PVL in which the antepartum fetal heart rate (FHR) patterns was normal. The 60 g hemorrhage from placental previa was the only antenatal event. Based on this case, the author investigated PVL cases with and without abnormal FHR patterns in the Japanese cerebral palsy registration database. The point raised by the author is interesting. Since the author has already revised the manuscript several times in response to suggestions from some reviewers, further additional revisions are unlikely. However, I would like to make the following requests. I would like the author to clarify the definitions of moderate and severe decelerations in the analysis of JOCSC database. It is desirable to clarify that no MSDs mean reassuring fetal status without late decelerations, decreased baseline variability, or tachycardia. The pathophysiology of PVL has been reported to be multifactorial, but principally initiated by hypoxia-ischemia and/or systemic inflammation. Hemorrhage due to placental previa could lead to fetal hypoperfusion, which could affect vascular supply of fetal white matter. To date, we do not have accurate tools to evaluate this other than FHR monitoring or ultrasound during pregnancy. Minor comment: (Table 1.) “Urinalysis pH” seems to be “Umbilical artery pH”. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Perinatology, Neonatology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (0) Kodama Y. Peer Review Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.140504.r301453) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/9-241/v4#referee-response-301453 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2020 Jung E. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 01 Sep 2020 | for Version 3 Euiseok Jung , Department of Pediatrics, University of Ulsan, Seoul, South Korea 0 Views copyright © 2020 Jung E. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (2) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The author has revised the article at my request. Well worth it to index. However, there is a typing mistake in the Discussion section and correction is required; "They reported that ntrauterine infection ... causing the injury by itself." Competing Interests No competing interests were disclosed. Reviewer Expertise Neonatology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (2) Author Response 03 Sep 2020 Shunji Suzuki, Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan Dear Dr. Euiseok Jung, I would like to thank you for the comments and critique of my manuscript. Sincerely, Shunji Suzuki View more View less Competing Interests No competing Interest. reply Respond Report a concern Author Response 04 Nov 2022 Shunji Suzuki, Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan Dear Professor Euiseok Jung, I am very sorry for the very late reply. Thank you very much for your guidance. I fixed a spelling mistake. Sincerely, Shunji Suzuki View more View less Competing Interests None. reply Respond Report a concern Jung E. Peer Review Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.28959.r70219) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/9-241/v3#referee-response-70219 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2020 Jung E. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 17 Aug 2020 | for Version 2 Euiseok Jung , Department of Pediatrics, University of Ulsan, Seoul, South Korea 0 Views copyright © 2020 Jung E. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The authors reported a case of PVL that was attributed to the placenta previa itself, despite the absence of moderate/severe decelerations. Similar cases were analyzed together based on Japanese cerebral palsy registration data. In the Discussion, previous researches suggested the possible pathophysiology that placenta previa could induce PVL. However, rather than simply listing suggestions from past cases, the author should specifically describe which of these possibilities are more relevant in relation to this case. Please change the author's name of reference #9 to Kumazaki and describe it in Discussion section. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Partly Competing Interests No competing interests were disclosed. Reviewer Expertise Neonatology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (0) Jung E. Peer Review Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.26264.r68656) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/9-241/v2#referee-response-68656 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2020 Londero A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 27 Apr 2020 | for Version 1 Ambrogio Pietro Londero , Clinic of Obstetrics and Gynecology, DAME, ASUI - Presidio Ospedaliero Universitario "SM della Misericordia", University of Udine, Udine, Italy 0 Views copyright © 2020 Londero A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (2) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions I read the article by Suzuki S entitled: "Placenta previa as a risk factor for antenatal- and peripartum periventricular leukomalacia resulting in cerebral palsy in Japan: a retrospective study" with interest. The argument is very interesting but I have some points to highlight in order to improve the manuscript itself: Major issues: The abstract does not reflect in a proper manner the content of the manuscript. In particular, the conclusion in the abstract is a clear overstatement. In fact, the data analyzed in the manuscript do not allow any kind of conclusion about a correlation between placenta previa and neonatal periventricular leukomalacia. In the dataset, only cases of neonatal periventricular leukomalacia without controls are present. For the same reason, the title of the article is also not appropriate, and also the manuscript's main-text itself should be fixed. For the clinical case report, I suggest following the CARE guidelines. Minor issues: A minor issue is that the clarity of the whole manuscript would benefit from a revision of the English language. Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? Partly Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? No Competing Interests No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (2) Author Response 04 May 2020 Shunji Suzuki, Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan Thank you very much for the comments and critique of my manuscript. I have been able to respond positively to each suggestion and we believe the paper has been strengthened. The changes are highlighted with red color. I have re-written the abstract, case report and the title according to your suggestions. In addition, my English has been edited. Thank you very much for your suggestions, again. I do hope and trust that with these changes the manuscript is now acceptable for publication. Thank you for considering my paper. Sincerely yours, Shunji Suzuki, MD Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital 5-11-12-2 Tateishi, Katsushika-ku, Tokyo 124-0012 Japan Tel: +81-3-3693-5211 Fax: +81-3-3694-8725 e-mail: [email protected] View more View less Competing Interests There are no competing interests. reply Respond Report a concern Author Response 04 Nov 2022 Shunji Suzuki, Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika-ku, 124-0012, Japan Dear Professor Ambrogio Pietro Londero、 Thank you very much for your previous suggestions. I have responded to your questions on May 2020. If you have further suggestions. Please guide me, again. Sincerely, Shunji Suzuki View more View less Competing Interests None. reply Respond Report a concern Londero AP. Peer Review Report For: Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 2 approved, 1 approved with reservations] . F1000Research 2024, 9 :241 ( https://doi.org/10.5256/f1000research.25256.r62089) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/9-241/v1#referee-response-62089 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. 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