The role of SK3 in progesterone-induced inhibition of human fallopian tubal contraction

Duo Zhang, Qian Zhu, Wei Xia, Chenfeng Zhu, Xiaoya Zhao, Yiqin Zhang, Chuqing He, Sifan Ji, Xiaocui Li, Jian Zhang
In: Reproductive Biology and Endocrinology · 2022 · vol. 20(1) , pp. 73 · doi:10.1186/s12958-022-00932-3 · PMID:35488306 · W4225124509
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Abstract

BACKGROUND: channel 3 (SK3) is abundantly expressed in platelet-derived growth factor receptor α positive (PDGFRα+) cells and was reported to be important for the relaxation of smooth muscle. The present study aims to explore the expression of SK3 in the human fallopian tube and its role in progesterone-induced inhibition of tubal contraction. METHODS: We collected specimens of fallopian tubes from patients treated by salpingectomy for EP (EP group) and other benign gynecological diseases (Non-EP group). The expression of SK3 was detected by quantitative real-time polymerase chain reaction, western blot, immunocytochemistry, and immunohistochemistry analyses. Isometric tension experiments were performed to investigate the role of SK3 in progesterone-induced inhibition of tubal contraction. RESULTS: channels may be involved. SK3-expressing PDGFRα (+) cells were detected in the human fallopian tube. CONCLUSIONS: The expression of SK3 is lower in the EP group, and SK3 is involved in the progesterone-induced inhibition of human fallopian tube contraction.

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chemicals 57
progesterone progesterone progesterone progesterone progesterone levonorgestrel progesterone progesterone progesterone progesterone progesterone progesterone estradiol progesterone formaldehyde nitrogen sucrose phenylindole hydroxymethylphosphonic acid sodium sulfate polyacrylamide macromolecule vinylidene fluoride penicillin streptomycin triton tetraethylammonium progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone estrogen progesterone progesterone progesterone progesterone progesterone progesterone progesterone estradiol
organisms 28
human human human human human human humans human rodents mus sp. old world monkeys human human korat cats korat cats rabbits korat cats horseradish korat cats human human humans noordeloos 2009062 mus sp. noordeloos 2009062 endosymbiont of paramecium polycaryum old world monkeys human

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