Elevated circulatory proline to glutamine ratio (PQR) in Patients with endometriosis revealed by targeted NMR based serum metabolomics

Kusum Kusum, Ritu Raj, Radha Chaube, Dinesh Kumar
2021 · doi:10.5281/zenodo.5179906 · W4393792519
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Targeted NMR-based serum metabolomics revealed elevated circulatory proline to glutamine ratios in endometriosis patients, indicating this metric may serve as an indicative biomarker for improving the clinical diagnosis of the condition.

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This study utilized targeted NMR-based serum metabolomics to investigate the metabolic profiles of women with endometriosis, a chronic condition characterized by extra-uterine growth of uterine lining tissue. The researchers hypothesized that mitochondrial dysfunction and reduced proline oxidase activity would lead to an accumulation of proline relative to glutamine in circulation. They found that patients with endometriosis exhibited significantly elevated circulatory proline-to-glutamine ratios compared to controls, suggesting this metric could serve as a potential biomarker for clinical diagnosis. This paper is centrally about endometriosis, focusing on identifying specific metabolic alterations associated with the disease.

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Abstract

Endometriosis (EM) is a chronic pain condition affecting women in reproductive age and involves the growth of uterine lining (endometrium) outside of the uterus. EM is often associated with altered inflammatory and immune processes and shares some cancer-like characteristics such as activated glutaminolysis. However, preclinical studies suggest mitochondrial dysfunction and decreased energy production in uterine endometriosis tissue. As proline catabolism in mitochondria serve as an important source of energy production and previous transcriptomics studies have demonstrated that there is reduced activity of proline oxidase (POX, a mitochondrial inner-membrane flavoenzyme involved in the catabolic degradation of the proline) due to overexpression of microRNA (known as MiR-23b). Based on this, we hypothesized and demonstrated that circulatory proline to glutamine ratio (PQR) are elevated in the EM patients and may serve as an indicative biomarker to improve the clinical diagnosis of EM.
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Elevated circulatory proline to glutamine ratio (PQR) in Patients with endometriosis revealed by targeted NMR based serum metabolomics Authors/Creators - 1. Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi-221005, UP, India - 2. Centre of Biomedical Research, SGPGIMS Campus, Lucknow-226014, Uttar Pradesh, India - 3. Molecular Diagnostics and Phenome Research Unit Contributors Data collector: Data curator: Data manager: Supervisor: - 1. Centre of Biomedical Research, SGPGIMS Campus, Lucknow-226014, Uttar Pradesh, India - 2. Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi-221005, UP, India Description Endometriosis (EM) is a chronic pain condition affecting women in reproductive age and involves the growth of uterine lining (endometrium) outside of the uterus. EM is often associated with altered inflammatory and immune processes and shares some cancer-like characteristics such as activated glutaminolysis. However, preclinical studies suggest mitochondrial dysfunction and decreased energy production in uterine endometriosis tissue. As proline catabolism in mitochondria serve as an important source of energy production and previous transcriptomics studies have demonstrated that there is reduced activity of proline oxidase (POX, a mitochondrial inner-membrane flavoenzyme involved in the catabolic degradation of the proline) due to overexpression of microRNA (known as MiR-23b). Based on this, we hypothesized and demonstrated that circulatory proline to glutamine ratio (PQR) are elevated in the EM patients and may serve as an indicative biomarker to improve the clinical diagnosis of EM.

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