CASE REPORT: Resolution of Chemotherapy-Induced Lymphopenia in Waldenström’s Macroglobulinemia Following Compassionate Use of WF10

CASE REPORT: Resolution of Chemotherapy-Induced Lymphopenia in Waldenström’s Macroglobulinemia Following Compassionate Use of WF10 | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report CASE REPORT: Resolution of Chemotherapy-Induced Lymphopenia in Waldenström’s Macroglobulinemia Following Compassionate Use of WF10 Friedrich-Wilhelm Kühne, Ulrike Jentzsch-Kühne, Jörg Flemmig This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7589797/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Bendamustin-Rituximab (BR) chemotherapy controls clonal B-cell expansion in Waldenström’s macroglobulinemia (WM) but may aggravate anemia and induce persistent lymphopenia. In the presented patient, the drug WF10 restored immune balance, reduced inflammation, and resolved anemia without interfering with chemotherapy (CT) effects on the tumor clone. No dedicated drug exists to counteract CT-induced lymphopenia in WM, despite its link to infections and secondary malignancies. This case highlights Immunokine as a post-CT option for resolving persistent lymphopenia, abating systemic inflammation, and restoring immune balance in WM patients. Tangible benefits included resolution of infection susceptibility, improved energy, and abatement of anemia – translating into better quality of life and resilience under CT. In the presented case, persistence of grade 1 lymphopenia suggests further WF10 treatment cycles may achieve full immune reconstitution. Waldenström’s macroglobulinemia lymphopenia anemia Myeloid-Lymphoid Dysbalance WF10 Immunokine Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7589797","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":516987202,"identity":"aad0b111-e62e-4dcf-bec1-ef6c6d28df18","order_by":0,"name":"Friedrich-Wilhelm Kühne","email":"","orcid":"","institution":"OXO Translational Science GmbH","correspondingAuthor":false,"prefix":"","firstName":"Friedrich-Wilhelm","middleName":"","lastName":"Kühne","suffix":""},{"id":516987203,"identity":"179ef5df-a33a-4a86-b761-cf7b4218881c","order_by":1,"name":"Ulrike Jentzsch-Kühne","email":"","orcid":"","institution":"Praxis Jentsch-Kühne / Rosenstein","correspondingAuthor":false,"prefix":"","firstName":"Ulrike","middleName":"","lastName":"Jentzsch-Kühne","suffix":""},{"id":516987204,"identity":"a1958ebb-bf2f-4094-bbfc-63a1bbdee87a","order_by":2,"name":"Jörg Flemmig","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAzUlEQVRIiWNgGAWjYBACxubDDUBKgoEfJtBAUEtbIkSLJIg6QIwWBrZEiBqDA8RqYW5jbHx0M8fCbvPxHsPHH/4wyPYTdhhjs3HuNonkbWeOJRscbGMwnknIGsb5jW3SIC1mN5KPSRxsYEjccICwLe2/QVqMZyS2SRz4w5C4nwgtbcxALXYGEkBbDrABbSHGLyCHJUiA/HK2TcJ4BiFbDNuYD37O3VZnz9/eY/ig4o+NbH8DIS1QBdDYAcYpQSAPpe0JKx0Fo2AUjIIRCwBtMkWYzRtohwAAAABJRU5ErkJggg==","orcid":"","institution":"OXO Translational Science GmbH","correspondingAuthor":true,"prefix":"","firstName":"Jörg","middleName":"","lastName":"Flemmig","suffix":""}],"badges":[],"createdAt":"2025-09-11 08:53:26","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7589797/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7589797/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":91815955,"identity":"d23ff68e-6065-4a97-9775-044dfef9fbd1","added_by":"auto","created_at":"2025-09-22 06:37:40","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":232778,"visible":true,"origin":"","legend":"","description":"","filename":"20250911manuscriptWMOTSrev1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7589797/v1/8d44bfc66879cd7a62e8d36b.pdf"},{"id":91815954,"identity":"644b2962-4660-4347-a659-84eed88ffa89","added_by":"auto","created_at":"2025-09-22 06:37:40","extension":"json","order_by":1,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":4894,"visible":true,"origin":"","legend":"","description":"","filename":"4f1c58dd9bda44bf8388add8af4751fa.json","url":"https://assets-eu.researchsquare.com/files/rs-7589797/v1/9488dc42e1b540f7cd0fa046.json"},{"id":92536679,"identity":"7827118c-d6e1-4f97-82da-fc7f2e01eb9f","added_by":"auto","created_at":"2025-09-30 17:31:38","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":269256,"visible":true,"origin":"","legend":"","description":"","filename":"20250911manuscriptWMOTSrev1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7589797/v1_covered_c99927d8-dd8c-47f4-9379-986dea864b20.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"CASE REPORT: Resolution of Chemotherapy-Induced Lymphopenia in Waldenström’s Macroglobulinemia Following Compassionate Use of WF10","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Waldenström’s macroglobulinemia, lymphopenia, anemia, Myeloid-Lymphoid Dysbalance, WF10, Immunokine","lastPublishedDoi":"10.21203/rs.3.rs-7589797/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7589797/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Bendamustin-Rituximab (BR) chemotherapy controls clonal B-cell expansion in Waldenström’s macroglobulinemia (WM) but may aggravate anemia and induce persistent lymphopenia. 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