Electrochemical Borylation of Carboxylic Acids

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AI-generated summary by claude@2026-07, 2026-07-26

This study describes an electrochemical method for converting carboxylic acids into borylated compounds using inexpensive carbon electrodes in an undivided cell, demonstrating broad substrate scope and scalability.

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Abstract

A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

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europepmc
last seen: 2026-05-19T01:45:01.086888+00:00