Features of genitalia microbiocenosis in women with hyperproliferative diseases and cervical pathology

Valentyna Kondratiuk, А. І. Нарольська, N. E. Gorban, Е. G. Danilenko
In: Likarska sprava · 2016 · pp. 44–53 · doi:10.31640/ls-2016(3-4)08 · W4362713762
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This study analyzed genital microbiocenosis in women with adenomyosis, leiomyoma, and chronic salpingitis, revealing distinct microbial defects such as lactobacilli deficits and increased pathogens associated with these conditions.

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This study analyzed genital tract microbiocenosis in 150 women with hyperproliferative diseases and cervical pathology, categorizing them into groups based on the presence of leiomyoma, adenomyosis, or chronic salpingitis. Researchers identified significant structural defects in microbial balance across all groups, including reduced lactobacilli and increased pathogenic bacteria such as Gardnerella, Staphylococcus, and Chlamydia, with the most severe dysbiosis observed in patients with combined leiomyoma and adenomyosis. The findings indicate a strong association between these uterine conditions and disrupted cervical microecology, suggesting that differentiated treatment targeting infectious agents is necessary to restore normal flora. Relevance to endometriosis: adenomyosis is explicitly studied as one of the hyperproliferative disease groups alongside leiomyoma and chronic salpingitis.

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Abstract

The features of structural defects of genital tract microbiocenosis in 150 patients with hyperproliferative diseases and disorders of the cervix were studied: group A – leiomyoma + chronic salpingitis; group B – adenomyosis + chronic salpingitis; group C – leiomyoma + adenomyosis + chronic salpingitis; group D – chronic salpingitis. Among patients of groups A and B – was found a significant increase in registration of gardnerellas, deficit of lactoflora, the formation of viral and bacterial associations. In patients of group C – the most frank defects of cervical canal microecology: increased frequency and quantity of potentially pathogenic microorganisms during seeding (Staphylococcus, Streptococcus, Escherichia), elimination or a significant deficit of lactobacilli, increased frequency of Gardnerelliosis, Chlamydia, and viral infections diagnosis. In patients of group D – increased frequency and quantitative level of registration of fungi F. Candida in association with Gram-positive cocci, enterobacteria and viruses. The findings suggest the necessity of differentiated treatment methods aimed at elimination of infectious agents and renewal of cervix normocenosis in women with hyperproliferative diseases and cervical pathology.
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Features of genitalia microbiocenosis in women with hyperproliferative diseases and cervical pathology DOI: https://doi.org/10.31640/LS-2016(3-4)08Keywords: microbiocenosis of genitals, hyperproliferativ ediseases, cervical pathology, leiomyoma, adenomyosis, chronic salpingitis.Abstract The features of structural defects of genital tract microbiocenosis in 150 patients with hyperproliferative diseases and disorders of the cervix were studied: group A – leiomyoma + chronic salpingitis; group B – adenomyosis + chronic salpingitis; group C – leiomyoma + adenomyosis + chronic salpingitis; group D – chronic salpingitis. Among patients of groups A and B – was found a significant increase in registration of gardnerellas, deficit of lactoflora, the formation of viral and bacterial associations. In patients of group C – the most frank defects of cervical canal microecology: increased frequency and quantity of potentially pathogenic microorganisms during seeding (Staphylococcus, Streptococcus, Escherichia), elimination or a significant deficit of lactobacilli, increased frequency of Gardnerelliosis, Chlamydia, and viral infections diagnosis. In patients of group D – increased frequency and quantitative level of registration of fungi F. Candida in association with Gram-positive cocci, enterobacteria and viruses. The findings suggest the necessity of differentiated treatment methods aimed at elimination of infectious agents and renewal of cervix normocenosis in women with hyperproliferative diseases and cervical pathology. Downloads References Бадалова Л. А., Роговская С. И. Клиническая и экономическая оценка методов профилактики вирусных поражений шейки матки // Пробл. женского здоровья. – 2011. – Т. 6, № 2. – С. 57. Бенюк В. А., Ластовецкая Л. Д., Щерба Е. А., Ковалюк Т. В. Медикаментозная коррекция вульвовагинита, обусловленного ассоциированной герпес-кандидозной инфекцией // Здоровье женщины. – 2009. – Вып. 40, № 4. – С. 198–199. Буянова С. Н., Мгелиашвили М. В., Петракова С. А. Современные представления об этиологии, патогенезе и морфогенезе миомы матки // Рос. вестн. акушера-гинеколога. – 2008. – Т. 8, № 6. – С. 45–51. Васильєва Н. А., Івахів О. Л. Оптимізація лікування пацієнтів з уреаплазмозом // Інфек. хвороби. – 2010. – № 2. – С. 17–21. Вовк І. Б., Кондратюк В. К., Калюта А. О. та ін. Кольпоскопічна та цитоморфологічна оцінка стану шийки матки у жінок репродуктивного віку з генітальним ендометріозом: Зб. наук. праць асоціації акушерів-гінекологів України. – К., 2012. – С. 76–78. Давидян О. В. Репродуктивное здоровье женского населения как медико-социальная проблема // Молодой учёный. – 2011. – Т. 2, № 2. – С. 152–153. Дерек С. М. Папіломавірусна інфекція як хвороба ХХІ століття: сучасні підходи до ведення пацієнтів // Мед. аспекты здоровья женщины. – 2011. – № 5. – С. 45–50. Катаханова О. А. Роль ВПЧ в генезе неопластических процессов шейки матки. Оптимизация лечебной тактики // Врач. – 2009. – Т. 3. – С. 23–26. Килимчук В. Урогенітальний хламідіоз у жінок: сучасні підходи до діагностики та лікування // Здоров’я України. – 2010. – Вип. 14, № 3. – С. 67. Патология шейки матки и генитальные инфекции / Под ред. В. Н. Прилепской. – М.: МЕДпресс-информ, 2008. – 480 с. Туркевич О. Ю. Комплексне лікування жінок з бактеріальним вагінозом на тлі герпесвірусної та папіломавірусної інфекції з урахуванням стану піхвового мікробіоценозу та імунологічного статусу хворих // Укр. журн. дерматології, венерології, косметології. – 2011. – Вип. 40, № 1. – С. 89–96. Garcia L., Isaacson K. Adenomyosis: review of the literature // J. Minim. Invasive Gynecol. – 2011. – Vol. 18, N 4. – Р. 428– 437. Novellas S., Chassang M., Delotte J. et al. MRI characteristics of the uterine junctional zone: from normal to the diagnosis of adenomyosis. // Am. J. Roentgenol. – 2011. – Vol. 196, N 5. – Р. 1206–1213. Downloads Published How to Cite Issue Section License Copyright (c) 2016 V. K. Kondratiuk, A. I. Narolska, N. E. Gorban, Е. G. Danilenko This work is licensed under a Creative Commons Attribution 4.0 International License.

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