Effect of Macrophage Migration Inhibitory Factor Antagonist on Endometriosis

Objective: To investigate the macrophage migration inhibitoryfactor antagonist(ISO-1)on the endometriosis.Methods: Endometrial heterotopic disease mice models were build,and treated with macrophage cell migration inhibition factor antagonists to intervene,the mice survival and weight were observed.Matrix metalloproteinase-2(MMP-2)-2,matrix metalloproteinase inhibitors(TIMP-2),vascular endothelial growth factor(VEGF) and TNF-alpha mRNA expressions were detected by RT-PCR,ELISA was used to detect the TNF-α protein expression.Results: There were no significant effect on survival rate after ISO-1 intervene,but the body weight improved(P0.05),and expressions of MMP-2,of VEGF,TNF-αreduced in endometrial endometriosis mice(P 0.05),the expression of TIMP-2 were not changed.Conclusion: The macrophage migration inhibitory factor was specific inhibitor,may significantly inhibit the reconstruction of damaged tissue,angiogenesis and inflammation,and ultimately affect tissue growth and further deterioration of endometriosis,which may be of clinical treatment of uterine endometriosis of the new strategy.