Network Pharmacological Studies on the Mechanism of Zexie Decoction in the treatment of Vertigo

Zexie Decoction which was composed of Zexie (Alisma orientale) and Baizhu (Atractylodes macrocephala) played an important role in the treatment of vertigo. The methods of network pharmacology were used to explore the possible targets of the effective components of Zexie Decoction in the treatment of vertigo. 12 main active components were selected and screened out in this study, containing 8 compounds from Alisma orientale and 4 compounds from Atractylodes macrocephala. 331 targets of active ingredients, including MAPK1, EGFR, MAPK14, ERBB2, PIK3CA were determined as the target proteins for the active site for the Zexie Decoction in the treatment of vertigo. The results of KEGG pathway enrichment analysis showed that it mainly involved Proteoglycans in cancer, ErbB signaling pathway, HIF-1 signaling pathway, chord metabolism in cancer, Estrogen signaling pathway, Prolactin signaling pathway and osteogenic class differentiation, etc. This study reflected the characteristics of multi-component, multi-target and multi-channel action of compound Zexie Decoction, providing new ideas and targets for the intervention mechanism of Zexie Decoction on vertigo.