Depressive mixed state and anxious distress as risk factors for suicidality during major depressive episodes

Depressive mixed state and anxious distress as risk factors for suicidality during major depressive episodes | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Depressive mixed state and anxious distress as risk factors for suicidality during major depressive episodes Kazuki Ota, Hotaka Shinzato, Naoaki Otsuka, Yu Zamami, Kazuhiro Kurihara, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4689398/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 07 Apr, 2025 Read the published version in Scientific Reports → Version 1 posted 11 You are reading this latest preprint version Abstract Accurately assessing and predicting suicidality in patients with depression are challenging for researchers and clinicians. We examined various risk factors for suicidality during major depressive episodes (MDE), especially focusing on depressive mixed state (DMX) and anxious distress (AD). We recruited 187 patients with MDE and divided them into two groups—with and without suicidality—defined as the cut-off score of 1 or more on the suicidality sub-item in the Quick Inventory of Depressive Symptomatology-Self Report. The presence of DMX was defined as a total score of 13 or more on the self-administered 8-item questionnaire for DMX. We used multivariate logistic regression analysis with the presence or absence of suicidality as a dependent variable for investigating factors associated with suicidality. The with suicidality group was younger and indicated a greater proportion of past suicide attempts, AD, and DMX than the without suicidality group. Logistic regression analysis revealed that AD (P = 0.047) and DMX (P = 0.018) were significantly associated with suicidality. AD and DMX may promote suicidality during MDE. These two psychopathological features should be carefully monitored and intensively treated for the prevention of suicide-related events. Biological sciences/Neuroscience/Emotion Biological sciences/Neuroscience/Social neuroscience anxious distress depressive mixed state DMX-8 major depressive episodes suicidality Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 07 Apr, 2025 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 15 Jan, 2025 Reviews received at journal 12 Jan, 2025 Reviewers agreed at journal 20 Dec, 2024 Reviews received at journal 24 Nov, 2024 Reviewers agreed at journal 14 Nov, 2024 Reviewers agreed at journal 29 Oct, 2024 Reviewers invited by journal 04 Oct, 2024 Editor assigned by journal 01 Oct, 2024 Editor invited by journal 11 Jul, 2024 Submission checks completed at journal 08 Jul, 2024 First submitted to journal 04 Jul, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4689398","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":332791960,"identity":"9dd46b24-337e-4e63-a7b3-21f25514f328","order_by":0,"name":"Kazuki Ota","email":"","orcid":"","institution":"University of the Ryukyus","correspondingAuthor":false,"prefix":"","firstName":"Kazuki","middleName":"","lastName":"Ota","suffix":""},{"id":332791961,"identity":"177c745c-07ab-447f-96a5-817ba17c2311","order_by":1,"name":"Hotaka Shinzato","email":"","orcid":"","institution":"University of the 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We examined various risk factors for suicidality during major depressive episodes (MDE), especially focusing on depressive mixed state (DMX) and anxious distress (AD). We recruited 187 patients with MDE and divided them into two groups—with and without suicidality—defined as the cut-off score of 1 or more on the suicidality sub-item in the Quick Inventory of Depressive Symptomatology-Self Report. The presence of DMX was defined as a total score of 13 or more on the self-administered 8-item questionnaire for DMX. We used multivariate logistic regression analysis with the presence or absence of suicidality as a dependent variable for investigating factors associated with suicidality. The with suicidality group was younger and indicated a greater proportion of past suicide attempts, AD, and DMX than the without suicidality group. Logistic regression analysis revealed that AD (P = 0.047) and DMX (P = 0.018) were significantly associated with suicidality. 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