Effect of Xiao Chaihu Decoction on the Expression of Cyclooxygenase-2 in Endometriosis Rats
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Xiao Chaihu Decoction treatment of endometriosis rats reduced cyclooxygenase-2 expression in ectopic endometrium, suggesting a mechanism involving prostaglandin reduction.
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Abstract
Objective To explore the therapeutic mechanism of Xiao Chaihu Decoction for endometriosis in rats. Methods The rat models of endometriosis were treated with Xiao Chaihu Decoction, Danazol, and Xiao Chaihu Decoction plus Danazol for 4 weeks,respectively. And then cyclooxygenase-2(COX-2) expression in endometrium and endometriotic tissue was observed by immunohistochemistry method. Results The expression of COX-2 in the endometriotic tissue was lower than that in endometrium in Xiao Chaihu Decoction group and Xiao Chaihu Decoction plus Danazol group, while the results in Danazol group and control group were opposed to those in the above two groups. Conclusion The mechanism of Xiao Chaihu Decoction for rats endometriosis may be related to the decrease of COX-2 expression in ectopic Endometrium, thus reducing the formation of prostaglandins.
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- last seen: 2026-06-10T17:14:06.276822+00:00
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