Guided Synthesis of the stable sols based on nanosized titanium(IV) oxides with the predictable particle size and antimicrobial properties

Guided Synthesis of the stable sols based on nanosized titanium(IV) oxides with the predictable particle size and antimicrobial properties | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Guided Synthesis of the stable sols based on nanosized titanium(IV) oxides with the predictable particle size and antimicrobial properties Asiya Gainanova, Aleksandr Glushko, Alexey Neznanov, Galina Kuz’micheva, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5843786/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The article discusses the targeted synthesis of sols with nanosized titanium(IV) oxides for biological and medical applications, as well as a doping agent precursor in obtaining crystals from solutions. When preparing sols without using surfactants, the synthesis conditions were changed: temperature and duration of hydrolysis, composition and concentration of titanium-containing precursors, stabilizing acid concentration. The resulting sols have different hydrodynamic diameter of titanium(IV) oxide nanoparticles (from ~2 to 2000 nm) and different stability (from 0 to 90 days). A specific set of machine learning tools was developed for well-interpretable analysis of experimental data. These tools were used in three stages of experiments to optimize three functional characteristics of the synthesized sols by varying five synthesis parameters. As a result, a universal minimalistic mechanism for the targeted synthesis of sols with the required characteristics was proposed, allowing for a reduction in the number of experiments and the study of the relationships between synthesis parameters and functional characteristics in various experiments. sols titanium(IV) oxides particle size stability computational chemistry machine-learning Full Text Additional Declarations The authors declare no competing interests. Supplementary Files Supplementarymaterialforreview.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5843786","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":403144521,"identity":"e2ce3ff2-aeff-4302-a78f-a485a067bcae","order_by":0,"name":"Asiya 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