From Quiescence to Self-Sustained Activity: How Astrocytes Reshape Neural Dynamics

From Quiescence to Self-Sustained Activity: How Astrocytes Reshape Neural Dynamics | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article From Quiescence to Self-Sustained Activity: How Astrocytes Reshape Neural Dynamics Den Whilrex Garcia, Sabir Jacquir This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4643799/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Astrocytes are currently gaining attention from the neuroscience community due to their contribution to a multitude of functions, which includes but are not limited to their ability to change the neuron's spiking frequency, their capacity to alter neuron's firing activity, and their involvement in memory formation and synaptic plasticity regulation. To date, many computational models describing the dynamics of astrocytes, together with their complex interaction with neurons, were proposed, however, these could still be improved since the exploration of their functions and mechanisms was way later than neurons. Hence, in this paper, investigation of the steady state behavior of the neuron-astrocyte interaction through a presentation of phase plane analysis and one parameter bifurcation were primarily performed. Adaptive Exponential Integrate-and-Fire model was utilized to describe the firing dynamics of the neuron while the model from the work of Postnov and collaborators was used to describe the calcium dynamics of the astrocyte. The findings demonstrate that astrocytic modulation can significantly shape neuronal activity, including initiating spikes, inducing self-sustained oscillations, and exerting both inhibitory and excitatory effects depending on synaptic strength. These highlight the crucial role that the contribution of astrocytes to the synapse plays in regulating neuronal activity and producing a range of neuronal firing behaviors within the neuron-astrocyte ensemble. They may impact neuronal synchronization, an attribute of several neurological illnesses, including epilepsy, and, on the other hand, may enhance brain information processing. Computational Neuroscience neuron astrocyte tripartite synapse calcium dynamics phase plane analysis Full Text Additional Declarations The authors declare no competing interests. Supplementary Files SupplementaryResults.pdf Supplementary Results GraphicalAbstract.jpg Graphical Abstract Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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