Expression of CA-125 Level And Neutrophil to Lymphocyte Ratio In Infected And Non-infected Endometrioma

In: KnE Medicine · 2017 · vol. 1(1) , pp. 173 · doi:10.18502/kme.v1i1.638 · W2601097041
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This study measured CA-125 and neutrophil-to-lymphocyte ratio (NLR) in infected and non-infected endometriomas to assess immune cell involvement in endometriosis progression.

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This conference proceedings study evaluated whether serum CA-125 and systemic inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR) and related leukocyte measures, differed between women with infected and non-infected endometriomas, based on an association of infected endometrioma with revised ASRM stage III–IV. The authors report that CA-125 had very low sensitivity and specificity for predicting endometrioma, while NLR functioned as a simple systemic inflammation marker. A major caveat noted in the abstract framing is that CA-125 has been used to monitor endometriosis progress but is not reliable for prediction on its own, motivating measurement of multiple blood markers. This paper is centrally about endometriosis—infected versus non-infected endometrioma with CA-125 and neutrophil-to-lymphocyte ratio comparisons.

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Abstract

Implantation and growth of endometriosis was determined by immune cell. There were several immunologic cells that promoting implantation and cell proliferation such as macrophages, Natural killer, lymphocyte and monocyte. Infected endometrioma was associated in women with revised American Society for Reproductive Medicine (ASRM) stage III-IV. Neutrophil lymphocyte ratio (NLR) was a simple systemic inflammation response markers. The sensitivity and spesificity CA-125 in predicting endometrioma was very low but it had been used to monitor the progress of endometriosis. Therefore, measuring mean in leucocyte, NLR, PLR and CA-125 level in infected endometrioma was necessary.
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Abstract

Implantation and growth of endometriosis was determined by immune cell. There were several immunologic cells that promoting implantation and cell proliferation such as macrophages, Natural killer, lymphocyte and monocyte. Infected endometrioma was associated in women with revised American Society for Reproductive Medicine (ASRM) stage III-IV. Neutrophil lymphocyte ratio (NLR) was a simple systemic inflammation response markers. The sensitivity and spesificity CA-125 in predicting endometrioma was very low but it had been used to monitor the progress of endometriosis. Therefore, measuring mean in leucocyte, NLR, PLR and CA-125 level in infected endometrioma was necessary.

References

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