A Computational Model of Hydrogen Peroxide Production in Liver and its Removal by Catalase and GSH-reliant Enzymes that Can Predict Intracellular H2O2Concentration and Cell Death During Incidents of Extreme Oxidative Stress: (1) Applications to PBPK/PD Modeling of the Trivalent Arsenical DMAIII, (2) Insights Obtained into (a) the Role of Critical GSH Depletion in Apoptosis and (b) How Intracellular H2O2Concentration is So Tightly Regulated

doi:10.1101/2023.09.03.556145

A Computational Model of Hydrogen Peroxide Production in Liver and its Removal by Catalase and GSH-reliant Enzymes that Can Predict Intracellular H2O2Concentration and Cell Death During Incidents of Extreme Oxidative Stress: (1) Applications to PBPK/PD Modeling of the Trivalent Arsenical DMAIII, (2) Insights Obtained into (a) the Role of Critical GSH Depletion in Apoptosis and (b) How Intracellular H2O2Concentration is So Tightly Regulated

2023 · doi:10.1101/2023.09.03.556145

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