Risks associated with premature ovarian failure in Han Chinese women

Huidan Wang, Haitao Chen, Yingying Qin, Zhuqing Shi, Xiaoming Zhao, Jianfeng Xu, Bowen Ma, Zi‐Jiang Chen
In: Reproductive BioMedicine Online · 2015 · vol. 30(4) , pp. 401–407 · doi:10.1016/j.rbmo.2014.12.013 · PMID:25682306 · W1978078358
article OA: bronze CC0 ⤵ 2 in-corpus citations
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This paper investigates the risks of premature ovarian failure in Han Chinese women.

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Abstract

In this retrospective study, the relationship between demographic characteristics, past medical history, general lifestyle habits and susceptibility of premature ovarian failure (POF) in Han Chinese population was investigated. Five hundred and fifty-three patients with POF and 400 women with normal ovarian function were recruited. A questionnaire was designed to gather information from responders. Logistic regression was carried out to calculate odds ratios (OR), 95% confidence intervals (95% CI) and P-values. History of pelvic surgery, mumps, having relatives with menstrual abnormalities and exposure to chemical agents were significantly associated with increased risk of POF (OR 5.53 [2.15 to 14.23]; 3.26 [2.38 to 4.47]; 28.12 [8.84 to 89.46]; 4.47 [2.09 to 9.58]). Vegetarian diet, tea and mineral water consumption reduced the risk of POF (OR 0.27 [0.19 to 0.37]; 0.04 [0.03 to 0.07]; 0.63 [0.47 to 0.85], respectively). Heredity, pelvic surgery, mumps and exposure to chemical agents were identified as risk factors for POF, whereas vegetarian diet, tea consumption and mineral water drinking were protective. Therefore, genetic consultation could help those women whose relatives manifested an early or premature menopause to avoid the consequences of possible premature ovarian function cessation. Avoidance of exposure to endocrine disrupters and flavonoids intake should be considered.

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