Sclerotherapy versus surgery in endometriomas. Clinical trial

This current randomized clinical trial compares the effectiveness of ethanol sclerotherapy for preserving fertility and recurrences against laparoscopic cystectomy. The recurrence rate was similar between the two groups, with rates of 21.2% (14 of 66) in the surgery group and 19.1% (17 of 89) in the sclerotherapy group (p=0.8). In the subset of women wanting to become pregnant, rates of pregnancy were notably higher in the sclerotherapy group (26 of 40, 65%) than in the surgery group (13 of 26, 50%), and significantly earlier. Mean direct hospital costs were significantly lower in the sclerotherapy group than in the laparoscopic group: 472 versus 2128 euros. Complications were low in both groups (12%), most of which were grade I-II, although in the surgery group 4.1% were grade III. The results are similar by protocol and as treated analyses.