Comparison of prognostic between partial and radical nephrectomy for T1b renal cell carcinoma: a propensity score ‐ matched SEER database analysis

Comparison of prognostic between partial and radical nephrectomy for T1b renal cell carcinoma: a propensity score ‐ matched SEER database analysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Comparison of prognostic between partial and radical nephrectomy for T1b renal cell carcinoma: a propensity score ‐ matched SEER database analysis Heqian Liu, Jiawei wang, Lingsong Tao, Yingqing Liu, Hou-bao Huang This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6114752/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 8 You are reading this latest preprint version Abstract Objective Renal cell carcinoma (RCC) is one of the most common tumors of the urinary system.Herein, we examined the epidemiology and prognostic factors of RCC and investigatedthe prognosis of partial nephrectomy (PN) compared to radical nephrectomy (RN) forT1b RCC over the past 20 years. Methods We obtained data from the Surveillance, Epidemiology, and End Results (SEER)-17(2000–2021) database for epidemiological and survival analysis. Results The age-adjusted incidence of RCC per 100,000 persons significantly increased from9.3 to 13.2 (annual percent change [APC]: 1.3%, 95% CI: 1.0–1.7). The mortality alsoincreased from 0.8 to 4.3 (APC: 4.1%, 95% CI: 3.2–5.0). The incidence of RCCpatients who underwent PN significantly increased from 0.9 to 4.7(APC:6.4%, 95% CI:4.9–7.9). Moreover, mortality for patients who underwent PN increased from 0% to0.3% (APC: 13.0%, 95% CI: 11.4–14.6%), while mortality for those who underwent RNincreased from 0.3% to 2.3% (APC: 3.6%, 95% CI: 2.2–5.0%). The multivariate Coxmodel indicated that PN was an independent predictor of good prognosis for both ACMand CSM, before and after propensity score matching . In addition, Kaplan-Meiersurvival curves showed that the RN group had a higher risk of both ACM and CSM. Conclusion In the present study, we demonstrated that both the incidence and mortality of RCChave increased over the past 20 years. The number of RCC patients undergoing PNhas also risen significantly in recent years. Our findings indicate that PN confers asurvival benefit compared to RN. Biological sciences/Cancer/Cancer therapy Biological sciences/Cancer/Urological cancer Full Text Additional Declarations No competing interests reported. Supplementary Files SMD.Plot.pdf SMD.Plot.2.pdf ROC.PS.pdf Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 15 May, 2025 Reviews received at journal 16 Apr, 2025 Reviewers agreed at journal 16 Apr, 2025 Reviewers invited by journal 16 Apr, 2025 Editor invited by journal 15 Apr, 2025 Editor assigned by journal 15 Apr, 2025 Submission checks completed at journal 27 Mar, 2025 First submitted to journal 26 Mar, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6114752","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":444000903,"identity":"ba61fb7e-b6ba-41d7-931b-b34ddf1ceacd","order_by":0,"name":"Heqian 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analysis","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-6114752/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6114752/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Objective \nRenal cell carcinoma (RCC) is one of the most common tumors of the urinary system.Herein, we examined the epidemiology and prognostic factors of RCC and investigatedthe prognosis of partial nephrectomy (PN) compared to radical nephrectomy (RN) forT1b RCC over the past 20 years.\nMethods \nWe obtained data from the Surveillance, Epidemiology, and End Results (SEER)-17(2000–2021) database for epidemiological and survival analysis.\nResults\nThe age-adjusted incidence of RCC per 100,000 persons significantly increased from9.3 to 13.2 (annual percent change [APC]: 1.3%, 95% CI: 1.0–1.7). The mortality alsoincreased from 0.8 to 4.3 (APC: 4.1%, 95% CI: 3.2–5.0). The incidence of RCCpatients who underwent PN significantly increased from 0.9 to 4.7(APC:6.4%, 95% CI:4.9–7.9). Moreover, mortality for patients who underwent PN increased from 0% to0.3% (APC: 13.0%, 95% CI: 11.4–14.6%), while mortality for those who underwent RNincreased from 0.3% to 2.3% (APC: 3.6%, 95% CI: 2.2–5.0%). The multivariate Coxmodel indicated that PN was an independent predictor of good prognosis for both ACMand CSM, before and after propensity score matching . In addition, Kaplan-Meiersurvival curves showed that the RN group had a higher risk of both ACM and CSM.\nConclusion\nIn the present study, we demonstrated that both the incidence and mortality of RCChave increased over the past 20 years. The number of RCC patients undergoing PNhas also risen significantly in recent years. Our findings indicate that PN confers asurvival benefit compared to RN.","manuscriptTitle":"Comparison of prognostic between partial and radical nephrectomy for T1b renal cell carcinoma: a propensity score ‐ matched SEER database analysis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-04-17 21:05:47","doi":"10.21203/rs.3.rs-6114752/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-05-15T13:34:14+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-04-16T06:10:01+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"61477496241055108302373408474868066576","date":"2025-04-16T06:09:13+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-04-16T04:21:06+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2025-04-15T04:55:43+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-04-15T04:53:42+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-03-27T14:55:53+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scientific Reports","date":"2025-03-26T15:08:50+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"4ba2f88f-96c9-4c17-ac25-99acc773e5e5","owner":[],"postedDate":"April 17th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":47273291,"name":"Biological sciences/Cancer/Cancer therapy"},{"id":47273292,"name":"Biological sciences/Cancer/Urological cancer"}],"tags":[],"updatedAt":"2025-07-31T08:23:37+00:00","versionOfRecord":[],"versionCreatedAt":"2025-04-17 21:05:47","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6114752","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6114752","identity":"rs-6114752","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}