Investigating the evolution of Inflamatory gastrointestinal disease over time

Investigating the evolution of Inflamatory gastrointestinal disease over time | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Investigating the evolution of Inflamatory gastrointestinal disease over time Mehari Gebre Teklezgi, Gebru Gebremeskel Gebrerufael This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4113110/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Inflammatory bowel disease (IBD) commonly refers to ulcerative colitis (UC) and Crohn disease (CD), which are chronic inflammatory diseases of the gastrointestinal (GI) tract of unknown etiology. This study was conducted to investigate the evolution of Ine flammatory bowel disease (IBD) score over time, and if this Ibd score depends in the treatment arms. Methodology: This is a clinical study which consisted of 291 sub: jects, who divided over four treatment arms and were measured durj ing a 7 week period. The Inflammatory bowel disease (IBD) score in the period Week 1 through Week 7 were considered as the outcome of interest, as well treatment was considered as predictor. Different statistical methods such as explanatory data analysis, linear and nons linear models were employed to explore the outcome of interest. Results From both the linear and nonlinear models, treatment were insignificant, however time, squared of time, cubic time and quartic time were significant in the linear mixed model.In the nonlinear case, time was revealed significant effect. Conclusions The two components are not related to the treat: ment,and as a result, the treatment does not completely explain the presence of potencial clusters in the outcome. Ibdsc0 partially explains the presence of potencial clusters in the outcome. Inflamatory bowel disease Linear mixed model Nonlinear mixed model Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4113110","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":333857879,"identity":"f03ddfe0-496c-4d09-92d3-c16ace2b5546","order_by":0,"name":"Mehari Gebre Teklezgi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4ElEQVRIiWNgGAWjYFACHiA2ADGYDwAJCRmitUgwsLElgLTwEKmFAaSFxwDBxQd023sPfq4oqKvjn9/z+dWNGgseBvbDRzfg02J25lyy5BmDwxISx3i3WeccAzqMJy3tBl4tN3IMJBsMDkgwALUY57ABtUjwmOHXcv+N8c8GgzoJ+WM8z4xz/hGj5QaPGdAWZgmDYzzMj3PbiNFyJsfMssHgsOTGY2lmzLl9EjxsBP1y/IzxzYY/dfxyhw8//pzzrU6On/3wMbxakAGbBJgkVjkIMH8gRfUoGAWjYBSMHAAAGg9D/29DvG4AAAAASUVORK5CYII=","orcid":"","institution":"Adigrat University","correspondingAuthor":true,"prefix":"","firstName":"Mehari","middleName":"Gebre","lastName":"Teklezgi","suffix":""},{"id":333857880,"identity":"a2b8d8bd-06ec-48ba-87df-4a82102594c8","order_by":1,"name":"Gebru Gebremeskel Gebrerufael","email":"","orcid":"","institution":"Adigrat University","correspondingAuthor":false,"prefix":"","firstName":"Gebru","middleName":"Gebremeskel","lastName":"Gebrerufael","suffix":""}],"badges":[],"createdAt":"2024-03-16 12:18:57","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4113110/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4113110/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":70913430,"identity":"1b12ac58-8ea7-4e61-8acb-f69addb75c3d","added_by":"auto","created_at":"2024-12-09 07:40:02","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":248937,"visible":true,"origin":"","legend":"","description":"","filename":"RevisedManuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4113110/v1_covered_9fc221ed-ada6-46d9-af79-40adcdd784a2.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Investigating the evolution of Inflamatory gastrointestinal disease over time","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Inflamatory bowel disease, Linear mixed model, Nonlinear mixed model","lastPublishedDoi":"10.21203/rs.3.rs-4113110/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4113110/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eInflammatory bowel disease (IBD) commonly refers to ulcerative colitis (UC) and Crohn disease (CD), which are chronic inflammatory diseases of the gastrointestinal (GI) tract of unknown etiology. This study was conducted to investigate the evolution of Ine flammatory bowel disease (IBD) score over time, and if this Ibd score depends in the treatment arms.\u003c/p\u003e\u003ch2\u003eMethodology:\u003c/h2\u003e \u003cp\u003eThis is a clinical study which consisted of 291 sub: jects, who divided over four treatment arms and were measured durj ing a 7 week period. The Inflammatory bowel disease (IBD) score in the period Week 1 through Week 7 were considered as the outcome of interest, as well treatment was considered as predictor. 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