Papillary clear cell adenocarcinoma of the groin arising from endometriosis

A E Klein, Klein AE, T W Bauer, Bauer TW, K E Marks, Marks KE, J L Belinson, Belinson Jl
Clinical orthopaedics and related research · 1999 · doi:10.1097/00003086-199904000-00025 · PMID:10212613
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A papillary clear cell adenocarcinoma in a 67-year-old woman was found to have arisen from extraabdominal endometriosis of the right groin, presenting as a rapidly enlarging thigh mass.

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This case report describes a 67-year-old woman presenting with a rapidly enlarging mass in her right anterior thigh, which was initially suspected to be a primary sarcoma. Histologic analysis of an incisional biopsy revealed papillary clear cell adenocarcinoma, leading researchers to conclude that the malignancy originated from extraabdominal endometriosis located in the groin region. The authors highlight specific clinical, radiographic, and histologic features to assist orthopaedic surgeons in recognizing this rare complication of extrapelvic endometriosis. This paper is centrally about endometriosis — specifically, the malignant transformation of extraabdominal endometriotic tissue into clear cell adenocarcinoma in an unusual anatomical location.

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Abstract

A 67-year-old woman presented with rapidly enlarging right anterior thigh mass. Clinical impression was of a primary sarcoma, but the histologic analysis of an incisional biopsy specimen showed adenocarcinoma with clear cell differentiation. Initially thought to be a metastasis, the malignant tumor appears to have arisen from extraabdominal endometriosis of the right groin. This case shows clinical, radiographic, and histologic findings that may help the orthopaedic surgeon recognize an unusual complication of extrapelvic endometriosis.
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Section II: Original Articles: Tumor Papillary Clear Cell Adenocarcinoma of the Groin Arising From Endometriosis - Adam E. Klein - Thomas W. Bauer - Kenneth E. Marks - Jerome L. Belinson Clinical Orthopaedics & Related Research 361:p 192-198, April 1999. A 67-year-old woman presented with a rapidly enlarging right anterior thigh mass. Clinical impression was of a primary sarcoma, but the histologic analysis of an incisional biopsy specimen showed adenocarcinoma with clear cell differentiation. Initially thought to be a metastasis, the malignant tumor appears to have arisen from extraabdominal endometriosis of the right groin. This case shows clinical, radiographic, and histologic findings that may help the orthopaedic surgeon recognize an unusual complication of extrapelvic endometriosis. Copyright © 1999 Lippincott Williams & Wilkins, Inc.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Adenocarcinoma, Papillary Endometriosis Inguinal Canal Muscular Diseases Soft Tissue Neoplasms Thigh Adenocarcinoma, Clear Cell Adenocarcinoma, Papillary Aged Cell Transformation, Neoplastic Cell Transformation, Neoplastic Diagnosis, Differential Endometriosis Female Humans Inguinal Canal Muscular Diseases Neoplasm Recurrence, Local Neoplasm Recurrence, Local

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