An Overview of Pathogenesis and Pathophysiology in Endometriosis

Nikolaos Tsampazis, Aris Daniilidis, Maria Mavromichali, Aristotelis Loufopoulos, Kostantinos Dinas, Charalampos Giannoulis
In: Current Women's Health Reviews · 2012 · vol. 8(2) , pp. 112–120 · doi:10.2174/157340412800194849 · W2324520529
article OA: closed CC0 ⤵ 2 in-corpus citations
Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This review summarizes pathogenic theories and pathophysiology models for endometriosis, emphasizing its multifactorial nature contributing to pain and subfertility.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-07, 2026-07-14 · read from full text ⓘ

This paper is a literature overview that searched Medline for articles and reviews using combinations of terms related to endometriosis and mechanistic themes such as inflammatory mediators, oxidative stress, immunity, infertility, pain, and peritoneal reactions. By synthesizing the selected literature, it argues that endometriosis is a collective term covering different disease entities in which multiple pathogenic mechanisms can contribute in varying combinations depending on phenotype. It further notes that the same multifactorial pattern extends to the pathophysiology underlying pain syndromes and infertility, which it identifies as major components of disease expression. This paper is centrally about endometriosis—specifically, it synthesizes evidence on multifactorial pathogenesis and pathophysiology mechanisms linked to pain and infertility.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Objective: This overview is aimed to summarize the pathogenic theories of endometriosis and to relate them to the various disease localizations and secondly, to sketch a pathophysiology model for the disease progress, namely the development of pain syndromes and subfertility. Materials-Methods: A yield of articles and reviews in Medline using key words in various combinations such as endometriosis, inflammatory mediators, oxidative stress, pathogenesis, pathophysiology, infertility, immunity, theory, pain, mullerianosis disease, and peritoneal reaction, has been reviewed and shortlisted on the basis of their reference to a particular pathogenesis mechanism or relation to pain and infertility. Results: An attempt to synthesize the collected information in an orderly manner has reinforced the notion of a holistic approach in the pathogenesis of the disease. “Endometriosis” is a rather collective term encompassing different disease entities. All mechanisms of pathogenesis may contribute in different combinations according to the disease phenotype. The same is true for the variety of pathophysiology mechanisms leading to pain syndromes and infertility, the two major components of the disease expression. Conclusion: The key issue in management is to recognize the multifactorial aspect of the disease in each case scenario before planning a therapeutical intervention. Keywords: Endometriosis, infertility, pain
Full text 1,158 characters · extracted from oa-doi-fallback · 4 sections · click to expand

Abstract

Materials-Methods: A yield of articles and reviews in Medline using key words in various combinations such as endometriosis, inflammatory mediators, oxidative stress, pathogenesis, pathophysiology, infertility, immunity, theory, pain, mullerianosis disease, and peritoneal reaction, has been reviewed and shortlisted on the basis of their reference to a particular pathogenesis mechanism or relation to pain and infertility.

Results

An attempt to synthesize the collected information in an orderly manner has reinforced the notion of a holistic approach in the pathogenesis of the disease. “Endometriosis” is a rather collective term encompassing different disease entities. All mechanisms of pathogenesis may contribute in different combinations according to the disease phenotype. The same is true for the variety of pathophysiology mechanisms leading to pain syndromes and infertility, the two major components of the disease expression.

Conclusion

The key issue in management is to recognize the multifactorial aspect of the disease in each case scenario before planning a therapeutical intervention.

Keywords

Endometriosis, infertility, pain

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisinfertility

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cited by (2)

Cited by (2)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK