A Phase III Clinical Trial of Buserelin versus Danazol in the Treatment of Endometriosis

W Matta, Robert W. Shaw
In: GnRH Analogues in Cancer and Human Reproduction · 1990 · pp. 39–42 · doi:10.1007/978-94-009-2169-6_5 · W4249545935
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This phase III trial investigated whether buserelin, a GnRH agonist causing hypoestrogenism, was superior to danazol for treating endometriosis.

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Abstract

Hormonal treatments for endometriosis which are aimed at suppressing the pituitary-ovarian function (‘pseudomenopause’) seem to be superior to those regimes aimed at inducing a ‘pseudopregnancy’ state. Hypo-oestrogenism can cause atrophy and regression of endometriotic tissue. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

Barbieri, RL, Evans, S and Kistner, RW (1982). Danazol in the treatment of endometriosis: analysis of 100 cases with a 4-year follow-up. Fertil Steril, 37, 737 Lemay, A, Maheux, R, Faure, N, Jean, C and Fazekas, ATA (1984). Reversible hypogonadism induced by a luteinizing hormone-releasing hormone (LHRH) agonist (Buserelin) as a new therapeutic approach for endometriosis. Fertil Steril, 41, 863 Shaw, RW and Matta, WHM (1986). Reversible pituitary ovarian suppression induced by an LHRH agonist in the treatment of endometriosis — comparison of two dose regimens. Clin Reprod Fertil, 4, 329 Revised American Fertility Society Classification of Endometriosis (1985). Fertil Steril, 43, 351 Matta, WHM, Shaw, RW, Hesp, R and Katz, D (1987). Hypogonadism induced by luteinising hormone releasing hormone agonist analogues: effects of bone density in premenopausal women. Brit Med J, 294, 1523 Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 1990 Springer Science+Business Media Dordrecht About this chapter Cite this chapter Matta, W.H.M., Shaw, R.W. (1990). A Phase III Clinical Trial of Buserelin versus Danazol in the Treatment of Endometriosis. In: Vickery, B.H., Lunenfeld, B. (eds) GnRH Analogues in Cancer and Human Reproduction. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2169-6_5 Download citation DOI: https://doi.org/10.1007/978-94-009-2169-6_5 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-010-7474-2 Online ISBN: 978-94-009-2169-6 eBook Packages: Springer Book Archive

Keywords

- GnRH Agonist - Endometriotic Lesion - Endometriotic Tissue - Cortical Bone Mineral Content - Revise American Fertility Society These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Condition tags

endometriosis

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