Young woman with multiple lung nodules: a pulmonary oxymoron

Thorax · 2022 · vol. 77(11) , pp. 1155–1157 · doi:10.1136/thorax-2022-218720 · PMID:35907637 · PMC9606538
Other OA: gold CC-BY-NC-4.0
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A young woman with asymptomatic multiple lung nodules was diagnosed with pulmonary leiomyomatosis, a benign smooth muscle tumor expressing estrogen receptor and WT-1, which resolved after hormone therapy.

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This case report describes a 31-year-old woman incidentally found to have multiple asymptomatic lung nodules, which were identified via surgical biopsy as benign metastasizing leiomyomatosis (PBML). The diagnosis was confirmed through immunohistochemistry showing positivity for smooth muscle markers and hormone receptors, alongside pelvic imaging that revealed a small uterine lesion suspected of being a fibroid or adenomyosis. Treatment with gonadotropin-releasing hormone analogues and progestins led to the regression of the pulmonary nodules, demonstrating the hormone-dependent nature of the disease. Relevance to endometriosis and adenomyosis: The paper identifies a uterine lesion suspected of being adenomyosis as the likely primary source of the pulmonary metastases, linking PBML directly to these gynecological conditions.

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This was a case of multiple asymptomatic pulmonary nodules in a young woman of childbearing age. In the case of multiple pulmonary nodules, it is useful to consider the distribution of the nodules on CT findings to narrow down the differential diagnosis. Although PBML is a rare disease, respiratory specialists should keep it in mind as a differential diagnosis for pulmonary nodules in young women.

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MeSH descriptors

Lung Neoplasms Lung Neoplasms Multiple Pulmonary Nodules Multiple Pulmonary Nodules Female Humans Lung Lung Magnetic Resonance Imaging

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europepmc
last seen: 2026-10-25T09:32:14.900964+00:00
pubmed
last seen: 2026-10-08T21:36:09.805877+00:00
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License: CC-BY-NC-4.0