Treatment of adenomyosis with a Levonorgestrel-releasing intrauterine device

Objective To evaluate the efficacy and safety of a Levonorgestrel-releasing intrauterine device (LNG-IUD) in treatment of adenomyosis.Methods To observe and compare the symptoms of dysmenorrhea,serum CA 125 ,volume of uterus,patterns of menstruation,and side-effect before and after LNG-IUD was inserted.Results The symptom of dysmenorrhea was relieved significantly one month after insertion,scores of pain decreased from 2.7 to 0.7(P0.01),and disappeared six month after insertion.The volume of uterus reduced six months after insertion and later,but without significant change (P0.05).Serum CA 125 reduced significantly(P0.01),down to the normal range three months after insertion,and remained at low level later.Conclusions Treatment of adenomyosis with a Levonorgestrel-releasing intrauterine device is a safe and effective conservative method.