STIP1 overexpression in endometriosis/adenomyosis.

Hsin-Shih Wang (8802), Chia-Lung Tsai (383111), Pi-Yueh Chang (123293), Angel Chao (123295), Ren-Chin Wu (167828), Shun-Hua Chen (170609), Chin-Jung Wang (4739508), Chih-Feng Yen (123288), Yun-Shien Lee (90565), Tzu-Hao Wang (14039)
2018 · doi:10.1371/journal.pone.0190573.g001 · W6941642829
other OA: green CC0
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Abstract

(A) Serum levels of STIP1 (left panel) and CA125 (right panel) were significantly higher in patients with endometriosis (EMS), adenomyosis (ADM), or coexisting endometriosis and adenomyosis (EMS/ADM) than in the age-matched controls. Statistical differences were calculated with Student’s t-test. *p < 0.05 and **p < 0.01. (B) Photomicrographs of immunohistochemical staining for STIP1 and MMP9 in a representative case of ovarian endometriosis and uterine adenomyosis taken with a 20× objective (upper panels) and 40× objective (lower panels) lens. Both ectopic endometrial epithelia (arrowheads) and stroma (stars) showed cytoplasmic expressions of STIP1 and MMP9, in both endometriosis and adenomyosis. Scale bars represent 100 μm. Abbreviations: EMS, endometriosis; ADM, adenomyosis.

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endometriosisadenomyosis

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