Correlation between hyperuricemia and cardiac remodeling in elderly patients with atrial fibrillation

Abstract BACKGROUND Studies have confirmed that patients with atrial fibrillation (AF) have a significantly increased risk of cardiovascular death, due to cardiac remodeling. Hyperuricemia (HUA) is also significantly associated with an increased risk of cardiovascular death. However, the correlation between HUA and cardiac remodeling in elderly patients with AF is still unclear; therefore, this study investigated the correlation between HUA and cardiac remodeling in elderly patients with AF. METHODS A total of 1153 hospitalized elderly patients with AF were retrospectively collected, and Serum uric acid (SUA) and echocardiography were measured to investigate the correlation between HUA and clinical indexes and cardiac remodeling in elderly patients with AF. RESULTS In elderly patients with AF, HUA was significantly associated with female sex, larger body mass index (BMI), lower estimated glomerular filtration rate (eGFR), and larger left ventricle (P < 0.05). CONCLUSION In elderly patients with AF, HUA was significantly associated with female sex, larger BMI, lower eGFR, and larger left ventricle.