High-Throughput Lipolysis in 96-Well Plates for Rapid Screening of Lipid-Based Drug Delivery Systems

Mette Dalskov Mosgaard; Philip Sassene; Huiling Mu; Thomas Rades; Anette Müllertz

doi:10.1016/j.xphs.2016.12.026

High-Throughput Lipolysis in 96-Well Plates for Rapid Screening of Lipid-Based Drug Delivery Systems

Mette Dalskov Mosgaard, Philip Sassene, Huiling Mu, Thomas Rades, Anette Müllertz

In: Journal of Pharmaceutical Sciences · 2017 · vol. 106(4) , pp. 1183–1186 · doi:10.1016/j.xphs.2016.12.026 · PMID:28057543 · W2570633741

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This study optimized a high-throughput in vitro intestinal lipolysis model for 96-well plates to rapidly screen lipid-based drug delivery systems, confirming it yields solubilization rank orders consistent with the original method.

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Abstract

The high-throughput in vitro intestinal lipolysis model (HTP) applicable for rapid and low-scale screening of lipid-based drug delivery systems (LbDDSs) was optimized and adjusted as to be conducted in 96-well plates (HTP-96). Three different LbDDSs (I-III) loaded with danazol or cinnarizine were used as model systems. The distributions of cinnarizine and danazol in the aqueous and precipitated digestion phases generated during lipolysis in HTP-96 were compared with previously published data obtained from HTP. The final HTP-96 setup resulted in the same rank order as the original HTP model with regard to solubilization in the aqueous phase during digestion: LbDDS III > LbDDS II > LbDDS I for danazol and LbDDS III ≈ LbDDS II ≈ LbDDS I for cinnarizine. HTP-96 is a useful model for fast performance assessment of LbDDS in a small scale.

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References (9)

doi:10.1016/s0928-0987(01)00169-5 via openalex
doi:10.1002/jps.23205 via openalex
doi:10.1177/026119299502300205 via openalex
doi:10.1016/j.ijpharm.2011.03.002 via openalex
doi:10.1016/j.ejpb.2015.06.028 via openalex
doi:10.1016/j.ijpharm.2013.03.054 via openalex
doi:10.1111/j.2042-7158.2010.01107.x via openalex
doi:10.14227/dt190312p15 via openalex
doi:10.1016/j.addr.2007.10.014 via openalex

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[1] doi:10.1016/s0928-0987(01)00169-5 via openalex

[2] doi:10.1002/jps.23205 via openalex

[3] doi:10.1177/026119299502300205 via openalex

[4] doi:10.1016/j.ijpharm.2011.03.002 via openalex

[5] doi:10.1016/j.ejpb.2015.06.028 via openalex

[6] doi:10.1016/j.ijpharm.2013.03.054 via openalex

[7] doi:10.1111/j.2042-7158.2010.01107.x via openalex

[8] doi:10.14227/dt190312p15 via openalex

[9] doi:10.1016/j.addr.2007.10.014 via openalex