Adsorption Isotherm and Kinetic Analysis of Sulfamethoxazole-Imprinted Polymers with two Functional Monomers using Bulk Polymerization

Adsorption Isotherm and Kinetic Analysis of Sulfamethoxazole-Imprinted Polymers with two Functional Monomers using Bulk Polymerization | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Adsorption Isotherm and Kinetic Analysis of Sulfamethoxazole-Imprinted Polymers with two Functional Monomers using Bulk Polymerization Adilah Mohamed Nageib, Amanatuzzakiah Abdul Halim, Anis Nurashikin Nordin, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7191391/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The analysis of adsorption isotherms and kinetics in molecularly imprinted polymers (MIPs) is vital for comprehending the interaction between target molecules and MIPs, thereby optimizing their functionality. These assessments offer valuable insights into the underlying mechanisms of adsorption, aid in the assessment of MIP synthesis parameters as well as enhancing the efficacy of MIP-based applications. Thus, this project aims to test the adsorption isotherm and kinetic analysis of sulfamethoxazole (SMX) antibiotic on MIPs using various adsorption models. The synthesis of MIPs was achieved using two monomers independently: methacrylic acid (MIP-MAA) and acrylamide (MIP-AA). Subsequently, the synthesized MIPs were characterized through surface morphology images using scanning electron microscope (SEM). The results from the four adsorption isotherm models applied showed that the Jovanovich model was the best fit followed by the Langmuir, Linear, and Freundlich models. Furthermore, among the three kinetic models evaluated, the Lagergren first-order model provided the best fit for MIP-MAA, while the pseudo-second-order model was most suitable for MIP-AA. The rate constant values were k1 = 0.54 min-1 for MIP-MAA and k2qe = 0.35 min-1 for MIP-AA at a concentration of 0.9 mM, respectively. These findings provide valuable insights into the adsorption mechanisms of SMX onto MIPs, showcasing MIPs as effective adsorbents for SMX that can be employed in efficient and precise methods for detecting antibiotic residues in various food products. Adsorption isotherm Bulk polymerization Kinetics Sulfamethoxazole Molecularly imprinted polymer Full Text Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7191391","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":503543084,"identity":"b3f19524-af3c-4013-9f90-8d672289966a","order_by":0,"name":"Adilah Mohamed Nageib","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Adilah","middleName":"Mohamed","lastName":"Nageib","suffix":""},{"id":503543085,"identity":"e82977fd-f8f4-4204-8653-a12a317a8de8","order_by":1,"name":"Amanatuzzakiah Abdul Halim","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAvElEQVRIiWNgGAWjYNCCCgkeMM1DvJYzJGthbIMyiNLCP+3wswc/51nIGFw7wPjgbRtDtMEBAlokbqeZG/Zuk+AxuJ3AbDi3jSF3AyEtDLcTzCR4IVrYpHmJ0SJ/O/2b5N85YC3sv4nSYnA7x0yatwFiCzNRWgxv55RJyxyT4JG8ndgsOeecRO5MQlrkbqdvk3xTU2fPdzv54Ic3ZTa5fYS0IAHGBiAhwaBAghYokG8gWcsoGAWjYBQMcwAAiKI/WtebwHYAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0002-5687-7384","institution":"International Islamic University Malaysia","correspondingAuthor":true,"prefix":"","firstName":"Amanatuzzakiah","middleName":"Abdul","lastName":"Halim","suffix":""},{"id":503543086,"identity":"09f7ffe0-269b-4e73-ae0a-b7f66aedf85f","order_by":2,"name":"Anis Nurashikin Nordin","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Anis","middleName":"Nurashikin","lastName":"Nordin","suffix":""},{"id":503543087,"identity":"3f713b98-57f5-4f87-a232-4d7c9331a091","order_by":3,"name":"Fathilah Ali","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Fathilah","middleName":"","lastName":"Ali","suffix":""}],"badges":[],"createdAt":"2025-07-23 02:47:18","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7191391/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7191391/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":92548708,"identity":"8a624661-638e-418b-b52f-ddcc5753e518","added_by":"auto","created_at":"2025-09-30 22:17:31","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1125825,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript2.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7191391/v1_covered_0b7cb339-94b8-4c7d-ad26-f2ed9ef4798c.pdf"}],"financialInterests":"","formattedTitle":"Adsorption Isotherm and Kinetic Analysis of Sulfamethoxazole-Imprinted Polymers with two Functional Monomers using Bulk Polymerization","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Adsorption isotherm, Bulk polymerization, Kinetics, Sulfamethoxazole, Molecularly imprinted polymer","lastPublishedDoi":"10.21203/rs.3.rs-7191391/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7191391/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"The analysis of adsorption isotherms and kinetics in molecularly imprinted polymers (MIPs) is vital for comprehending the interaction between target molecules and MIPs, thereby optimizing their functionality. These assessments offer valuable insights into the underlying mechanisms of adsorption, aid in the assessment of MIP synthesis parameters as well as enhancing the efficacy of MIP-based applications. Thus, this project aims to test the adsorption isotherm and kinetic analysis of sulfamethoxazole (SMX) antibiotic on MIPs using various adsorption models. The synthesis of MIPs was achieved using two monomers independently: methacrylic acid (MIP-MAA) and acrylamide (MIP-AA). Subsequently, the synthesized MIPs were characterized through surface morphology images using scanning electron microscope (SEM). The results from the four adsorption isotherm models applied showed that the Jovanovich model was the best fit followed by the Langmuir, Linear, and Freundlich models. Furthermore, among the three kinetic models evaluated, the Lagergren first-order model provided the best fit for MIP-MAA, while the pseudo-second-order model was most suitable for MIP-AA. The rate constant values were k1 = 0.54 min-1 for MIP-MAA and k2qe = 0.35 min-1 for MIP-AA at a concentration of 0.9 mM, respectively. 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