SPIROMETRY ASSESSMENTS IN CHILDREN WITH SICKLE CELL DISEASE IN GHANA AND FACTORS THAT CONTRIBUTE TO ABNORMAL LUNG FUNCTION- A CASE CONTROL STUDY.

SPIROMETRY ASSESSMENTS IN CHILDREN WITH SICKLE CELL DISEASE IN GHANA AND FACTORS THAT CONTRIBUTE TO ABNORMAL LUNG FUNCTION- A CASE CONTROL STUDY. | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 26 May 2025 V1 Latest version Share on SPIROMETRY ASSESSMENTS IN CHILDREN WITH SICKLE CELL DISEASE IN GHANA AND FACTORS THAT CONTRIBUTE TO ABNORMAL LUNG FUNCTION- A CASE CONTROL STUDY. Authors : Birgit Baah 0000-0002-8085-5556 , Ntim Emmanuel , Eugenia Osei , Vivian Paintsil , Joseph Boaheng , Marovza Nicola , Osei Akoto Alex , Daniel Ansong , Diane Gray , and Sandra Kwarteng Owusu 0000-0001-6439-1643 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174828128.86074416/v1 398 views 221 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: Sickle Cell Disease (SCD) is a genetic disorder in which red blood cells undergo episodes of sickling following hypoxemia. Episodes of ischaemic crisis in children are predicted to accelerate the decline in pulmonary function. There are few published reports on lung function assessments in children with sickle-cell disease in sub-Saharan Africa. This study aimed to investigate the association between patterns of spirometry assessment in children with SCD in Ghana. Method: A case-control study involving 115 children aged 6-16 years with SCD and 115 non-SCD controls was carried out at the Komfo Anokye Teaching Hospital. Demographic, socio-economic, and clinical information were collected. Spirometry was performed for 130 cases and controls at enrolment. Results: Children with SCD had lower lung volumes and lower anthropometric measurements compared to the controls: forced expiratory volume in 1 second (FEV 1 ), cases vs controls, 1.40L vs 1.80L, (p<0.001), forced vital capacity (FVC), cases vs controls,1.70L vs 2.10L, (p<0.001), body mass index(BMI), cases vs controls,16.0 kg/m 2 vs 17.2 kg/m 2 , (p= 0.002), height, cases vs controls, 135cm vs 143cm, (p<0.001) weight, cases vs controls, 31kg vs 38kg, (p<0.001). Restrictive abnormality on spirometry was predominant, 43% (n=49) in cases compared to 25% (n=29) in controls. Obstructive abnormality was uncommon. We observed an association between older age and restrictive pattern on spirometry (OR 1.53, 95% CI 1.23-21.91, p <0.001) as well as BMI and restrictive pattern on spirometry (OR 0.63, CI 0.48-0.81, p<0.001) Conclusion: This study has demonstrated a predominance of low anthropometric measurements and restrictive abnormality on spirometry in children with SCD in Ghana. Restrictive pulmonary function abnormality is associated with older age and lower BMI. Supplementary Material File (scd ghana manuscript 14 042024.version 4.0.docx) Download 204.65 KB File (tables- 04.docx) Download 30.19 KB Information & Authors Information Version history V1 Version 1 26 May 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords abnormal lung function children restrictive lung disease sicke cell disease spirometery Authors Affiliations Birgit Baah 0000-0002-8085-5556 Kwame Nkrumah University of Science and Technology View all articles by this author Ntim Emmanuel Kwame Nkrumah University of Science and Technology View all articles by this author Eugenia Osei Komfo Anokye Teaching Hospital View all articles by this author Vivian Paintsil Kwame Nkrumah University of Science and Technology View all articles by this author Joseph Boaheng Holland College Culinary The Culinary Institute of Canada View all articles by this author Marovza Nicola University of Cape Town View all articles by this author Osei Akoto Alex Kwame Nkrumah University of Science and Technology View all articles by this author Daniel Ansong Kwame Nkrumah University of Science and Technology View all articles by this author Diane Gray University of Cape Town Department of Paediatrics and Child Health View all articles by this author Sandra Kwarteng Owusu 0000-0001-6439-1643 [email protected] Kwame Nkrumah University of Science and Technology View all articles by this author Metrics & Citations Metrics Article Usage 398 views 221 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Birgit Baah, Ntim Emmanuel, Eugenia Osei, et al. SPIROMETRY ASSESSMENTS IN CHILDREN WITH SICKLE CELL DISEASE IN GHANA AND FACTORS THAT CONTRIBUTE TO ABNORMAL LUNG FUNCTION- A CASE CONTROL STUDY.. Authorea . 26 May 2025. DOI: https://doi.org/10.22541/au.174828128.86074416/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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