Inverse-Designed Plasmonic Biosensors with LSPR-SPP-Wood Anomaly Coupling Enhenced for Biomolecular Analysis

Inverse-Designed Plasmonic Biosensors with LSPR-SPP-Wood Anomaly Coupling Enhenced for Biomolecular Analysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Inverse-Designed Plasmonic Biosensors with LSPR-SPP-Wood Anomaly Coupling Enhenced for Biomolecular Analysis Yihui Yang, Youqian Chen, Rui Li, Wen Li, Mingqian Chen, Wenjun Hu, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7535309/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 16 Dec, 2025 Read the published version in Journal of Nanobiotechnology → Version 1 posted 9 You are reading this latest preprint version Abstract Investigating molecular interactions is crucial for advancing biological research and therapeutic discovery. Traditional analytical techniques often face limitations in sensitivity, quantification accuracy, and simplicity. Metasurfaces support resonances that are widely explored both for far-field wavefront shaping and for near-field sensing. Here, we introduce an innovative inverse-designed multilayer metasurface plasmon resonance (IDMM-SPR) sensor that overcomes these challenges. Using a double-objective optimization method, we developed a sensor with unparalleled sensitivity and stability, capable of analyzing ultra-high affinity and low molecular weight interactions. The IDMM-SPR sensor employs a periodic nanocup array with multilayer metallic materials, optimized through a combination of numerical simulations and machine learning. This design leverages collective resonances, including localized surface plasmon resonance (LSPR), Wood’s anomalies, and the Bloch wave surface plasmon polariton (BW-SPP), to enhance sensing performance. The sensor achieves a figure of merit (FoM) of 26.3 and a detection limit (LOD) for C-reactive protein (CRP) as low as 7.3 pM. Its compatibility with microplate absorbance readers and imaging detection makes it highly practical. The IDMM-SPR sensor demonstrates significant potential for high-throughput molecular interaction analysis, drug development, and disease diagnosis, offering a powerful tool for real-time, label-free detection and quantitative analysis of biomolecular interactions. Metasurface SPR numerical simulation biosensor molecular interaction Full Text Additional Declarations No competing interests reported. Supplementary Files 3JoNSI.docx Cite Share Download PDF Status: Published Journal Publication published 16 Dec, 2025 Read the published version in Journal of Nanobiotechnology → Version 1 posted Editorial decision: Revision requested 21 Oct, 2025 Reviews received at journal 21 Oct, 2025 Reviewers agreed at journal 01 Oct, 2025 Reviews received at journal 30 Sep, 2025 Reviewers agreed at journal 25 Sep, 2025 Reviewers invited by journal 25 Sep, 2025 Editor assigned by journal 06 Sep, 2025 Submission checks completed at journal 06 Sep, 2025 First submitted to journal 04 Sep, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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