Prostaglandin production by human myometrium, uterine cervix and leiomyoma

In: Prostaglandins, Leukotrienes and Medicine · 1987 · vol. 29(1) , pp. 107–112 · doi:10.1016/0262-1746(87)90102-8 · PMID:3478735 · W2047361206
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This study investigated prostaglandin production in human myometrium, uterine cervix, and leiomyoma tissues.

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Abstract

In order to investigate prostacyclin production by human myometrium, uterine cervix and leiomyoma, slices of each tissue were incubated. The 6-keto prostaglandin F1 alpha concentration of the incubation medium was measured by radioimmunoassay. The serosal and endometrial sides of myometrium produce 6-keto prostaglandin F1 alpha, with no significant difference in production between the two sides. The 6-keto PGF1 alpha production of leiomyoma was significantly higher than that of myometrium. Our results suggest that human myometrium and leiomyoma produce prostacyclin regardless of vascularization.

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SciLite annotations

chemicals 5
prostaglandin prostanoid 6-oxoprostaglandin f1alpha tetracenomycin f1 prostanoid
organisms 3
human human human

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