The effect of estradiol valerate and dienogest combination on serum homocysteine levels in postmenopausal women: A clinical trial

Z. Pirimoglu Meltem; Elif Ganime Aygün; Ramazan Dansuk; İnci Küçükercan; Orhan Ünal; Cem Turan

doi:10.1080/09513590500282190

The effect of estradiol valerate and dienogest combination on serum homocysteine levels in postmenopausal women: A clinical trial

Z. Pirimoglu Meltem, Elif Ganime Aygün, Ramazan Dansuk, İnci Küçükercan, Orhan Ünal, Cem Turan

In: Gynecological Endocrinology · 2005 · vol. 21(3) , pp. 185–188 · doi:10.1080/09513590500282190 · PMID:16335913 · W2064264565

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This clinical trial found that 6 months of estradiol valerate and dienogest therapy did not significantly alter serum homocysteine levels in postmenopausal women.

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Abstract

Several studies have verified that hormone replacement therapy (HRT) has protective effects on postmenopausal women's cardiovascular condition. However, highly significant recent studies have reported that women treated with HRT have more cardiovascular events than untreated women. An elevated homocysteine level is one important risk factor for cardiovascular disease (CVD). As a good indicator of CVD risk, we examined the changes in plasma homocysteine levels of postmenopausal women treated with HRT. In our study, we administered estradiol valerate (2 mg) and dionegest (2 mg) to 34 postmenopausal women recruited randomly from our menopause clinic, and measured plasma homocysteine levels of patients at baseline and after 3 and 6 months of therapy. The changes in plasma homocysteine levels of treated patients were not statistically significant (p = 0.241). Our results indicate that 6 months of estradiol valerate and dionegest therapy does not change homocysteine levels in postmenopausal women.

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Cites (1)

Estradiol Valerate/Dienogest 2002

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[1] Estradiol Valerate/Dienogest 2002