Risk Factors Associated to Poor Survival in Primary Breast Cancer of Premenopausal and Postmenopausal Patients: A Mexican-Based Population Study

Background: Breast cancer (BC) is the most prevalent neoplasm in the female gender, being also the leading cause of mortality in women worldwide. In Latin American countries such as Mexico, locally advanced and metastatic stages remain prevalent at the time of diagnosis. Factors involved in the progression of BC are highly interdependent elements, where non-modifiable risk factors, such as premenopausal and menopause play a significant role in BC prognosis[SG1] .Methods. Retrospective cohort study that analyzed clinicopathological variables of 292 cases of BC evaluating individual risk within premenopausal and postmenopausal women and probability of survival with a 5-year median follow-up.Results. Our results showed that overall survival (OS) rate for premenopausal and postmenopausal women at 5-years was 88.1% and 92.6%, respectively. Premenopausal showed over 3.6-fold increased risk of recurrence at early stages (p=0.0003), and decreased OS associated to larger tumors (>2 cm) (p=0.0290; HR 4.54; 95%CI 1.58-13.07). In postmenopausal women, we observed a significant effect on OS associated to negative estrogen receptor (ER–) status tumors (p=0.0014; HR 3.71; 95%CI 1.21-11.39), and Triple Negative (TN) subtype (p=0.0021; HR 4.72; 95%CI 1.05-21.28). These findings show differences between cohorts and briefly informs prognosis by menopausal status in a Mexican population-based study, in hopes of improved prevention and detection programmes.