Investigation on clinical efficacy of different ultra-low-doses mifepristone in treatment of adenomyosis

Objective:To explore the clinical efficacy of ultra-low-doses mifepristone in treatment of adenomyosis in women of childbearing age and observe its effect on endocrine function and metabolism.Methods:120 cases diagnosed as adenomyosis from May 2007 to November 2009 were divided into two groups randomly,60 cases in each group,and all the cases took mifepristone for 6 months,6 mg per day and 12 mg per day,respectively.Regular follow up was conducted,the clinical efficacy,adverse reactions and effect on endocrine function were compared between the two groups.Results:The symptom of dysmenorrhea in the two groups relieved,but there was no significant difference in total effectiveness rate between the two groups(χ2=1.01,P0.05);the rate of nausea and vomiting in the first group was 19.16%,which was significantly lower than that in the second group(53.12%).There was significant difference in serum level of progesterone between the two groups(P0.01).Conclusion:The two different ultra-low-doses mifepristone are both effective and safe in treatment of adenomyosis while the lower dose is recommended,which is more appropriate and has less impact on endocrine function.