CuO stabilized on magnetic decorated GO nanosheets efficiently promoted the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione and 1,4- dihydropyridine derivatives under green chemistry conditions

CuO stabilized on magnetic decorated GO nanosheets efficiently promoted the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione and 1,4- dihydropyridine derivatives under green chemistry conditions | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article CuO stabilized on magnetic decorated GO nanosheets efficiently promoted the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione and 1,4- dihydropyridine derivatives under green chemistry conditions Mohammad Eslami, Mohammad G. Dekamin, Elham Mahdavi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6440664/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 03 May, 2026 Read the published version in Scientific Reports → Version 1 posted 13 You are reading this latest preprint version Abstract This study presents a green, efficient, and sustainable method for synthesizing biologically active 3,4-dihydropyrimidin-2(1 H )-one/thione (3,4-DHPMs/3,4-DHPMTs) and 1,4-dihydropyridine (1,4-DHPs) heterocycles. The approach involves a one-pot, three-component condensation of aldehydes, 1,3-dicarbonyl compounds, and urea or ammonium carbonate, catalyzed by a magnetically separable CuO/mGO-TA-Me-BTA nanocomposite. The method adheres to green chemistry principles, offering advantages such as short reaction times, high yields, easy work-up, and the use of a recyclable, low-cost catalyst. The catalyst demonstrated remarkable stability and could be reused up to six times without significant loss of activity. The CuO/mGO-TA-Me-BTA nanocomposite was extensively characterized using Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX) spectrometry, elemental mapping, thermogravimetric analysis (TGA), atomic absorption spectroscopy (AAS), and vibrating sample magnetometry (VSM). Biological sciences/Cancer/Cancer imaging Biological sciences/Cancer/Cancer therapy Biological sciences/Chemical biology/Chemical libraries Biological sciences/Chemical biology/Small molecules Biological sciences/Drug discovery/Drug screening Biological sciences/Drug discovery/Medicinal chemistry Biological sciences/Drug discovery/Pharmaceutics Biological sciences/Chemical biology Biological sciences/Drug discovery Health sciences/Cardiology Health sciences/Molecular medicine Physical sciences/Chemistry Physical sciences/Chemistry/Catalysis Physical sciences/Chemistry/Chemical biology Physical sciences/Chemistry/Coordination chemistry Physical sciences/Chemistry/Green chemistry Physical sciences/Chemistry/Inorganic chemistry Physical sciences/Chemistry/Materials chemistry Physical sciences/Chemistry/Medicinal chemistry Physical sciences/Chemistry/Organic chemistry Physical sciences/Chemistry/Physical chemistry Physical sciences/Chemistry/Supramolecular chemistry Physical sciences/Chemistry/Surface chemistry Physical sciences/Chemistry/Synthesis Physical sciences/Materials science Physical sciences/Materials science/Materials for devices Physical sciences/Materials science/Materials for energy and catalysis Physical sciences/Materials science/Nanoscale materials Physical sciences/Materials science/Techniques and instrumentation Physical sciences/Nanoscience and technology Physical sciences/Nanoscience and technology/Graphene Physical sciences/Nanoscience and technology/Nanoscale devices Physical sciences/Nanoscience and technology/Nanoscale materials Physical sciences/Nanoscience and technology/Other nanotechnology Physical sciences/Nanoscience and technology/Techniques and instrumentation Full Text Additional Declarations No competing interests reported. Supplementary Files SupportingInformation1.pdf Cite Share Download PDF Status: Published Journal Publication published 03 May, 2026 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 12 May, 2025 Reviews received at journal 08 May, 2025 Reviews received at journal 25 Apr, 2025 Reviews received at journal 17 Apr, 2025 Reviewers agreed at journal 16 Apr, 2025 Reviewers agreed at journal 16 Apr, 2025 Reviewers agreed at journal 16 Apr, 2025 Reviewers agreed at journal 16 Apr, 2025 Reviewers invited by journal 16 Apr, 2025 Editor assigned by journal 15 Apr, 2025 Editor invited by journal 15 Apr, 2025 Submission checks completed at journal 14 Apr, 2025 First submitted to journal 13 Apr, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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